Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2

Guangshun Zhang , Junyuan Cao , Yan Cai , Yang Liu , Yanli Li , Peilin Wang , Jiao Guo , Xiaoying Jia , Mengmeng Zhang , Gengfu Xiao , Yu Guo , Wei Wang

Protein Cell ›› 2019, Vol. 10 ›› Issue (2) : 137 -142.

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Protein Cell ›› 2019, Vol. 10 ›› Issue (2) : 137 -142. DOI: 10.1007/s13238-018-0604-x
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Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2

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Guangshun Zhang, Junyuan Cao, Yan Cai, Yang Liu, Yanli Li, Peilin Wang, Jiao Guo, Xiaoying Jia, Mengmeng Zhang, Gengfu Xiao, Yu Guo, Wei Wang. Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2. Protein Cell, 2019, 10(2): 137-142 DOI:10.1007/s13238-018-0604-x

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References

[1]

Burgeson JR, Gharaibeh DN, Moore AL, Larson RA, Amberg SM, Bolken TC, Hruby DE, Dai D (2013a) Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus. Bioorg Med Chem Lett 23:5840–5843

[2]

Burgeson JR, Moore AL, Gharaibeh DN, Larson RA, Cerruti NR, Amberg SM, Hruby DE, Dai D (2013b) Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorg Med Chem Lett 23:750–756

[3]

Dai D, Burgeson JR, Gharaibeh DN, Moore AL, Larson RA, Cerruti NR, Amberg SM, Bolken TC, Hruby DE (2013) Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole. Bioorg Med Chem Lett 23:744–749

[4]

Grigoryan, G. (2011). DrawCoil 1.0.

[5]

Hastie KM, Zandonatti MA, Kleinfelter LM, Heinrich ML, Rowland MM, Chandran K, Branco LM, Robinson JE, Garry RF, Saphire EO (2017) Structural basis for antibody-mediated neutralization of Lassa virus. Science 356:923–928

[6]

Larson RA, Dai D, Hosack VT, Tan Y, Bolken TC, Hruby DE, Amberg SM (2008) Identification of a broad-spectrum arenavirus entry inhibitor. J Virol 82:10768–10775

[7]

Lee AM, Rojek JM, Spiropoulou CF, Gundersen AT, Jin W, Shaginian A, York J, Nunberg JH, Boger DL, Oldstone MB (2008) Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses. J Biol Chem 283:18734–18742

[8]

Lenz O, ter Meulen J, Klenk HD, Seidah NG, Garten W (2001) The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P. Proc Natl Acad Sci U S A 98:12701–12705

[9]

Shankar S, Whitby LR, Casquilho-Gray HE, York J, Boger DL, Nunberg JH (2016) Small-Molecule Fusion Inhibitors Bind the pH-Sensing Stable Signal Peptide-GP2 Subunit Interface of the Lassa Virus Envelope Glycoprotein. J Virol 90:6799–6807

[10]

Thomas CJ, Casquilho-Gray HE, York J, DeCamp DL, Dai D, Petrilli EB, Boger DL, Slayden RA, Amberg SM, Sprang SR (2011) A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junin hemorrhagic fever arenavirus. J Biol Chem 286:6192–6200

[11]

Wang P, Liu Y, Zhang G, Wang S, Guo J, Cao J, Jia X, Zhang L, Xiao G, Wang W (2018) Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drugs Library. J Virol 92: JVI–00954

[12]

Wang W, Zhou Z, Zhang L, Wang S, Xiao G (2016) Structurefunction relationship of the mammarenavirus envelope glycoprotein. Virol Sin 31:380–394

[13]

York J, Dai D, Amberg SM, Nunberg JH (2008) pH-induced activation of arenavirus membrane fusion is antagonized by small-molecule inhibitors. J Virol 82:10932–10939

[14]

York J, Nunberg JH (2009) Intersubunit interactions modulate pHinduced activation of membrane fusion by the Junin virus envelope glycoprotein GPC. J Virol 83:4121–4126

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