Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2

Guangshun Zhang; Junyuan Cao; Yan Cai; Yang Liu; Yanli Li; Peilin Wang; Jiao Guo; Xiaoying Jia; Mengmeng Zhang; Gengfu Xiao; Yu Guo; Wei Wang

doi:10.1007/s13238-018-0604-x

PDF(3556 KB)

Protein Cell ›› 2019, Vol. 10 ›› Issue (2) : 137-142. DOI: 10.1007/s13238-018-0604-x

LETTER

Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2

Guangshun Zhang¹^,²^,⁴^,⁵ ,
Junyuan Cao¹^,³ ,
Yan Cai²^,⁴^,⁵ ,
Yang Liu¹ ,
Yanli Li²^,⁴^,⁵ ,
Peilin Wang¹^,³ ,
Jiao Guo¹^,³ ,
Xiaoying Jia¹^,³ ,
Mengmeng Zhang²^,⁴^,⁵ ,
Gengfu Xiao¹^,³ ,
Yu Guo²^,⁴^,⁵ ,
Wei Wang¹^,³

Author information +

History +

Cite this article

EndNote

Ris (Procite)

Bibtex

Download citation ▾

Guangshun Zhang, Junyuan Cao, Yan Cai, Yang Liu, Yanli Li, Peilin Wang, Jiao Guo, Xiaoying Jia, Mengmeng Zhang, Gengfu Xiao, Yu Guo, Wei Wang. Structure-activity relationship optimization for lassa virus fusion inhibitors targeting the transmembrane domain of GP2. Protein Cell, 2019, 10(2): 137‒142 https://doi.org/10.1007/s13238-018-0604-x

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Burgeson JR, Gharaibeh DN, Moore AL, Larson RA, Amberg SM, Bolken TC, Hruby DE, Dai D (2013a) Lead optimization of an acylhydrazone scaffold possessing antiviral activity against Lassa virus. Bioorg Med Chem Lett 23:5840–5843 CrossRef Google scholar

[2]	Burgeson JR, Moore AL, Gharaibeh DN, Larson RA, Cerruti NR, Amberg SM, Hruby DE, Dai D (2013b) Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole and related heterocycles. Bioorg Med Chem Lett 23:750–756 CrossRef Google scholar

[3]	Dai D, Burgeson JR, Gharaibeh DN, Moore AL, Larson RA, Cerruti NR, Amberg SM, Bolken TC, Hruby DE (2013) Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole. Bioorg Med Chem Lett 23:744–749 CrossRef Google scholar

[4]	Grigoryan, G. (2011). DrawCoil 1.0.

[5]	Hastie KM, Zandonatti MA, Kleinfelter LM, Heinrich ML, Rowland MM, Chandran K, Branco LM, Robinson JE, Garry RF, Saphire EO (2017) Structural basis for antibody-mediated neutralization of Lassa virus. Science 356:923–928 CrossRef Google scholar

[6]	Larson RA, Dai D, Hosack VT, Tan Y, Bolken TC, Hruby DE, Amberg SM (2008) Identification of a broad-spectrum arenavirus entry inhibitor. J Virol 82:10768–10775 CrossRef Google scholar

[7]	Lee AM, Rojek JM, Spiropoulou CF, Gundersen AT, Jin W, Shaginian A, York J, Nunberg JH, Boger DL, Oldstone MB (2008) Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses. J Biol Chem 283:18734–18742 CrossRef Google scholar

[8]	Lenz O, ter Meulen J, Klenk HD, Seidah NG, Garten W (2001) The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P. Proc Natl Acad Sci U S A 98:12701–12705 CrossRef Google scholar

[9]	Shankar S, Whitby LR, Casquilho-Gray HE, York J, Boger DL, Nunberg JH (2016) Small-Molecule Fusion Inhibitors Bind the pH-Sensing Stable Signal Peptide-GP2 Subunit Interface of the Lassa Virus Envelope Glycoprotein. J Virol 90:6799–6807 CrossRef Google scholar

[10]

Thomas CJ, Casquilho-Gray HE, York J, DeCamp DL, Dai D, Petrilli EB, Boger DL, Slayden RA, Amberg SM, Sprang SR (2011) A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junin hemorrhagic fever arenavirus. J Biol Chem 286:6192–6200

CrossRef Google scholar

[11]	Wang P, Liu Y, Zhang G, Wang S, Guo J, Cao J, Jia X, Zhang L, Xiao G, Wang W (2018) Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drugs Library. J Virol 92: JVI–00954 CrossRef Google scholar

[12]	Wang W, Zhou Z, Zhang L, Wang S, Xiao G (2016) Structurefunction relationship of the mammarenavirus envelope glycoprotein. Virol Sin 31:380–394 CrossRef Google scholar

[13]	York J, Dai D, Amberg SM, Nunberg JH (2008) pH-induced activation of arenavirus membrane fusion is antagonized by small-molecule inhibitors. J Virol 82:10932–10939 CrossRef Google scholar

[14]	York J, Nunberg JH (2009) Intersubunit interactions modulate pHinduced activation of membrane fusion by the Junin virus envelope glycoprotein GPC. J Virol 83:4121–4126 CrossRef Google scholar