Protein & Cell >

2018 , Vol. 9 >Issue 9: 752 - 753

DOI: https://doi.org/10.1007/s13238-018-0570-3

HIGHLIGHT

Adenine base editing to mimic or correct disease mutations in rodents

  • Ruotong Ren 1,2,3 ,
  • Juan Carlos Izpisua Belmonte , 4 ,
  • Guang-Hui Liu , 1,2,3,5
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  • 1. Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • 2. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
  • 3. University of Chinese Academy of Sciences, Beijing 100049, China
  • 4. Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
  • 5. Institute of Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

Published date: 21 Sep 2018

Copyright

2018 The Author(s) 2018
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Cite this article

Ruotong Ren , Juan Carlos Izpisua Belmonte , Guang-Hui Liu . Adenine base editing to mimic or correct disease mutations in rodents[J]. Protein & Cell, 2018 , 9(9) : 752 -753 . DOI: 10.1007/s13238-018-0570-3

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Gaudelli NM, Komor AC, Rees HA, Packer MS, Badran AH, Bryson DI, Liu DR (2017) Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage. Nature 551:464–471

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2
Kim K, Ryu SM, Kim ST, Baek G, Kim D, Lim K, Chung E, Kim S, Kim JS (2017) Highly efficient RNA-guided base editing in mouse embryos. Nat Biotechnol 35:435–437

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3
Komor AC, Kim YB, Packer MS, Zuris JA, Liu DR (2016) Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage. Nature 533:420–424

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4
Liang P, Sun H, Sun Y, Zhang X, Xie X, Zhang J, Zhang Z, Chen Y, Ding C, Xiong Y(2017a) Effective gene editing by highfidelity base editor 2 in mouse zygotes. Protein Cell 8:601–611

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Liang P, Ding C, Sun H, Xie X, Xu Y, Zhang X, Sun Y, Xiong Y, Ma W, Liu Y (2017b) Correction of β-thalassemia mutant by base editor in human embryos. Protein Cell 8:811–822

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6
Liang P, Sun H, Zhang X, Xie X, Zhang J, Bai Y, Ouyang X, Zhi S, Xiong Y, Ma W(2018) Effective and precise adenine base editing in mouse zygotes. Protein Cell. https://doi.org/10.1007/s13238-018-0566-z

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Liu Z, Lu Z, Yang G, Huang S, Li G, Feng S, Liu Y, Li J, Yu W, Zhang Y (2018) Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing. Nat Commun 9:2338

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8
Ryu SM, Koo T, Kim K, Lim K, Baek G, Kim ST, Kim HS, Kim DE, Lee H, Chung E(2018) Adenine base editing in mouse embryos and an adult mouse model of Duchenne muscular dystrophy. Nat Biotechnol 36:536

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9
Yang L, Zhang X, Wang L, Yin S, Zhu B, Xie L, Duan Q, Hu H, Zheng R, Wei Y(2018) Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants. Protein Cell. https://doi.org/10.1007/s13238-018-0568-x

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