CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting
Published date: 14 Aug 2018
Copyright
Yuanyuan Zhang , Yi Liu , Liqun Chen , Yiguo Wang , Jinbo Han . CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting[J]. Protein & Cell, 2018 , 9(8) : 729 -732 . DOI: 10.1007/s13238-018-0538-3
1 |
Altarejos JY, Montminy M (2011) CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 12:141–151
|
2 |
Chen L, Wang K, Long A, Jia L, Zhang Y, Deng H, Li Y, Han J, Wang Y (2017) Fasting-induced hormonal regulation of lysosomal function. Cell Res 27:748
|
3 |
Goldstein JL, DeBose-Boyd RA, Brown MS (2006) Protein sensors for membrane sterols. Cell 124:35–46
|
4 |
Han J, Wang Y (2017) mTORC1 signaling in hepatic lipid metabolism. Protein Cell 9:145–151
|
5 |
Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, Deng H, Wang Y (2015) The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature 524:243–246
|
6 |
Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M (2003) CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature 426:190–193
|
7 |
Horton JD, Bashmakov Y, Shimomura I, Shimano H (1998) Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci USA 95:5987–5992
|
8 |
Li S, Brown MS, Goldstein JL (2010) Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci USA 107:3441–3446
|
9 |
Rui L (2014) Energy metabolism in the liver. Compr Physiol 4:177–197
|
10 |
Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6:77–86
|
11 |
Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller N, Liu Y, Hedrick S, Vera L, Montminy M (2010) Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci USA 107:3087–3092
|
12 |
Yabe D, Brown MS, Goldstein JL (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci USA 99:12753–12758
|
13 |
Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS (2003) Liverspecific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc Natl Acad Sci USA 100:3155–3160
|
14 |
Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH
|
15 |
Yellaturu CR, Deng X, Park EA, Raghow R, Elam MB (2009) Insulin enhances the biogenesis of nuclear sterol regulatory elementbinding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavageactivating protein (SCAP).SREBP-1c complex. J Biol Chem 284:31726–31734
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