CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting

Yuanyuan Zhang , Yi Liu , Liqun Chen , Yiguo Wang , Jinbo Han

Protein Cell ›› 2018, Vol. 9 ›› Issue (8) : 729 -732.

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Protein Cell ›› 2018, Vol. 9 ›› Issue (8) : 729 -732. DOI: 10.1007/s13238-018-0538-3
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CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting

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Yuanyuan Zhang, Yi Liu, Liqun Chen, Yiguo Wang, Jinbo Han. CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting. Protein Cell, 2018, 9(8): 729-732 DOI:10.1007/s13238-018-0538-3

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References

[1]

Altarejos JY, Montminy M (2011) CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 12:141–151

[2]

Chen L, Wang K, Long A, Jia L, Zhang Y, Deng H, Li Y, Han J, Wang Y (2017) Fasting-induced hormonal regulation of lysosomal function. Cell Res 27:748

[3]

Goldstein JL, DeBose-Boyd RA, Brown MS (2006) Protein sensors for membrane sterols. Cell 124:35–46

[4]

Han J, Wang Y (2017) mTORC1 signaling in hepatic lipid metabolism. Protein Cell 9:145–151

[5]

Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, Deng H, Wang Y (2015) The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature 524:243–246

[6]

Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M (2003) CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature 426:190–193

[7]

Horton JD, Bashmakov Y, Shimomura I, Shimano H (1998) Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci USA 95:5987–5992

[8]

Li S, Brown MS, Goldstein JL (2010) Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci USA 107:3441–3446

[9]

Rui L (2014) Energy metabolism in the liver. Compr Physiol 4:177–197

[10]

Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL (2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6:77–86

[11]

Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller N, Liu Y, Hedrick S, Vera L, Montminy M (2010) Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci USA 107:3087–3092

[12]

Yabe D, Brown MS, Goldstein JL (2002) Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci USA 99:12753–12758

[13]

Yabe D, Komuro R, Liang G, Goldstein JL, Brown MS (2003) Liverspecific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis. Proc Natl Acad Sci USA 100:3155–3160

[14]

Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH (2011) Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab 14:21–32

[15]

Yellaturu CR, Deng X, Park EA, Raghow R, Elam MB (2009) Insulin enhances the biogenesis of nuclear sterol regulatory elementbinding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavageactivating protein (SCAP).SREBP-1c complex. J Biol Chem 284:31726–31734

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