LETTER

The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival

  • Shilei Zhang 1,2 ,
  • Deng Pan 3 ,
  • Xin-Ming Jia 1 ,
  • Xin Lin , 2 ,
  • Xueqiang Zhao , 2
Expand
  • 1. Department of Immunology, Tongji University School of Medicine, Shanghai 200092, China
  • 2. Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing 100084, China
  • 3. Cancer Biology Program, Graduate School of Biomedical Sciences, The University of Texas, Houston, TX 77030, USA

Published date: 30 Nov 2017

Copyright

2017 The Author(s) 2017. This article is an open access publication

Cite this article

Shilei Zhang , Deng Pan , Xin-Ming Jia , Xin Lin , Xueqiang Zhao . The CARMA3-BCL10-MALT1 (CBM) complex contributes to DNA damage-induced NF-κB activation and cell survival[J]. Protein & Cell, 2017 , 8(11) : 856 -860 . DOI: 10.1007/s13238-017-0441-3

1
BitonS, AshkenaziA (2011) NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-alpha feedforward signaling.Cell145:92–103

DOI

2
BlonskaM, LinX (2011) NF-kappaB signaling pathways regulated by CARMA family of scaffold proteins.Cell Res21:55–70

DOI

3
Diaz BessoneMI, BerardiDE, CampodonicoPB, TodaroLB, LothsteinL, de KierBal, JoffeED, UrtregerAJ (2011) Involvement of PKC delta (PKCdelta) in the resistance against different doxorubicin analogs.Breast Cancer Res Treat126:577–587

DOI

4
GrabinerBC, BlonskaM, LinPC, YouY, WangD, SunJ, DarnayBG, DongC, LinX (2007) CARMA3 deficiency abrogates G proteincoupled receptor-induced NF-{kappa}B activation.Genes Dev21:984–996

DOI

5
HinzM, StilmannM, ArslanSC, KhannaKK, DittmarG, ScheidereitC (2010) A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-kappaB activation.Mol Cell40:63–74

DOI

6
JiangT, GrabinerB, ZhuY, JiangC, LiH, YouY, LangJ, HungMC, LinX (2011) CARMA3 is crucial for EGFR-Induced activation of NF-kappaB and tumor progression.Cancer Res71:2183–2192

DOI

7
JiangC, ZhouZ, QuanY, ZhangS, WangT, ZhaoX, MorrisonC, HeiseMT, HeW, MillerMS (2016) CARMA3 is a host factor regulating the balance of inflammatory and antiviral responses against viral infection.Cell Rep14:2389–2401

DOI

8
KatoT Jr, DelhaseM, HoffmannA, KarinM (2003) CK2 is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response.Mol Cell12:829–839

DOI

9
LiN, BaninS, OuyangH, LiGC, CourtoisG, ShilohY, KarinM, RotmanG (2001) ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks.J Biol Chem276:8898–8903

DOI

10
LiZ, QuL, DongQ, HuangB, LiH, TangZ, XuY, LuoW, LiuL, QiuX (2012) Overexpression of CARMA3 in non-small-cell lung cancer is linked for tumor progression.PLoS ONE7:e36903

DOI

11
MahanivongC, ChenHM, YeeSW, PanZK, DongZ, HuangS (2008) Protein kinase C alpha-CARMA3 signaling axis links Ras to NF-kappa B for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells.Oncogene27:1273–1280

DOI

12
PanD, ZhuY, ZhouZ, WangT, YouH, JiangC, LinX (2016) The CBM complex underwrites NF-kappaB activation to promote HER2-associated tumor malignancy.Mol Cancer Res14:93–102

DOI

13
PomerantzJL, DennyEM, BaltimoreD (2002) CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex.EMBO J21:5184–5194

DOI

14
WangD, YouY, CaseSM, McAllister-LucasLM, WangL, DiStefanoPS, NunezG, BertinJ, LinX (2002) A requirement for CARMA1 in TCR-induced NF-kappa B activation.Nat Immunol3:830–835

DOI

15
WuZH, WongET, ShiY, NiuJ, ChenZ, MiyamotoS, TergaonkarV (2010) ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.Mol Cell40:75–86

DOI

Outlines

/