RESEARCH HIGHLIGHT

Genome-wide in vivo screen identifies host molecule in promoting cancer metastasis

  • Yan Gu 1 ,
  • Yanfang Liu 1,2 ,
  • Xuetao Cao , 1,3
Expand
  • 1. National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pathology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • 3. Department of Immunology & Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China

Published date: 05 Jul 2017

Copyright

2017 The Author(s) 2017. This article is published with open access at Springerlink.com and journal.hep.com.cn

Cite this article

Yan Gu , Yanfang Liu , Xuetao Cao . Genome-wide in vivo screen identifies host molecule in promoting cancer metastasis[J]. Protein & Cell, 2017 , 8(6) : 398 -400 . DOI: 10.1007/s13238-017-0391-9

1
ChenF, QiX, QianM, DaiY, SunY (2014) Tackling the tumor microenvironment: what challenge does it pose to anticancer therapies?Protein Cell5:816–826

DOI

2
JoyceJA, FearonDT (2015) T cell exclusion, immune privilege, and the tumor microenvironment.Science348:74–80

DOI

3
LiuY, CaoX (2016) Characteristics and significance of the premetastatic niche.Cancer Cell30:668–681

DOI

4
LiuY, GuY, HanY, ZhangQ, JiangZ, ZhangX, HuangB, XuX, ZhengJ, CaoX (2016) Tumor exosomal RNAs promote lung premetastatic niche formation by activating alveolar epithelial TLR3 to recruit neutrophils.Cancer Cell30:243–256

DOI

5
MatloubianM, LoCG, CinamonG, LesneskiMJ, XuY, BrinkmannV, AllendeML, ProiaRL, CysterJG (2004) Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1.Nature427:355–360

DOI

6
PardollDM (2012) The blockade of immune checkpoints in cancer immunotherapy.Nat Rev Cancer12:252–264

DOI

7
QuailDF, JoyceJA (2013) Microenvironmental regulation of tumor progression and metastasis.Nat Med19:1423–1437

DOI

8
TanS, ChenD, LiuK, HeM, SongH, ShiY, LiuJ, ZhangCW, QiJ, YanJ (2016) Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies.Protein Cell7:866–877

DOI

9
vander Weyden L, ArendsMJ, CampbellAD, BaldT, Wardle-JonesH, GriggsN, Velasco-HerreraMD, TutingT, SansomOJ, KarpNA (2017) Genome-wide in vivo screen identifies novel host regulators of metastatic colonization.Nature541:233–236

DOI

10
WhiteJK, GerdinAK, KarpNA, RyderE, BuljanM, BussellJN, SalisburyJ, ClareS, InghamNJ, PodriniC (2013) Genomewide generation and systematic phenotyping of knockout mice reveals new roles for many genes.Cell154:452–464

DOI

Outlines

/