The Hippo pathway in tissue homeostasis and regeneration
Received date: 01 Dec 2016
Accepted date: 05 Jan 2017
Published date: 12 Jun 2017
Copyright
While several organs in mammals retain partial regenerative capability following tissue damage, the underlying mechanisms remain unclear. Recently, the Hippo signaling pathway, better known for its function in organ size control, has been shown to play a pivotal role in regulating tissue homeostasis and regeneration. Upon tissue injury, the activity of YAP, the major effector of the Hippo pathway, is transiently induced, which in turn promotes expansion of tissue-resident progenitors and facilitates tissue regeneration. In this review, with a general focus on the Hippo pathway, we will discuss its major components, functions in stem cell biology, involvement in tissue regeneration in different organs, and potential strategies for developing Hippo pathwaytargeted regenerative medicines.
Key words: Hippo; YAP; regeneration
Yu Wang , Aijuan Yu , Fa-Xing Yu . The Hippo pathway in tissue homeostasis and regeneration[J]. Protein & Cell, 2017 , 8(5) : 349 -359 . DOI: 10.1007/s13238-017-0371-0
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