REVIEW

The Hippo pathway in tissue homeostasis and regeneration

  • Yu Wang 1 ,
  • Aijuan Yu 1 ,
  • Fa-Xing Yu , 1,2,3
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  • 1. Children’s Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
  • 2. Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China
  • 3. Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Fudan University, Shanghai 200032, China

Received date: 01 Dec 2016

Accepted date: 05 Jan 2017

Published date: 12 Jun 2017

Copyright

2017 The Author(s) 2017. This article is published with open access at Springerlink.com and journal.hep.com.cn

Abstract

While several organs in mammals retain partial regenerative capability following tissue damage, the underlying mechanisms remain unclear. Recently, the Hippo signaling pathway, better known for its function in organ size control, has been shown to play a pivotal role in regulating tissue homeostasis and regeneration. Upon tissue injury, the activity of YAP, the major effector of the Hippo pathway, is transiently induced, which in turn promotes expansion of tissue-resident progenitors and facilitates tissue regeneration. In this review, with a general focus on the Hippo pathway, we will discuss its major components, functions in stem cell biology, involvement in tissue regeneration in different organs, and potential strategies for developing Hippo pathwaytargeted regenerative medicines.

Key words: Hippo; YAP; regeneration

Cite this article

Yu Wang , Aijuan Yu , Fa-Xing Yu . The Hippo pathway in tissue homeostasis and regeneration[J]. Protein & Cell, 2017 , 8(5) : 349 -359 . DOI: 10.1007/s13238-017-0371-0

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