LETTER

The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 (StarD3/MLN64), in BRIN-BD11 insulinoma cells

  • Joana Borges Pinto 1,2 ,
  • Annette Graham , 1
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  • 1. Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow G4 0BA, UK
  • 2. Present address WolfsonWohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Switchback Road, Bearsden, Glasgow G61 1QH, UK

Published date: 28 Nov 2016

Copyright

2016 The Author(s) 2016. This article is published with open access at Springerlink.com and journal.hep.com.cn

Cite this article

Joana Borges Pinto , Annette Graham . The role of endosomal cholesterol trafficking protein, StAR-related lipid transfer domain 3 (StarD3/MLN64), in BRIN-BD11 insulinoma cells[J]. Protein & Cell, 2016 , 7(11) : 833 -838 . DOI: 10.1007/s13238-016-0315-0

1
Alpy F, Rousseau A, Schwab Y, Legueux F, Stoll I, Wendling C, Spiegelhalter C, Kessler P, Mathelin C, Rio MC, Levine TP, Tomasetto C (2013) STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the ER. J Cell Sci 126:5500–5512

DOI

2
Borthwick F, Taylor JM, Bartholomew C, Graham A (2009) Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human (THP-1) macrophages. FEBS Lett 583:1147–1153

DOI

3
Borthwick F, Allen AM, Taylor JM, Graham A (2010) Over-expression of STARD3 in human monocyte-macrophages induces an antiatherogenic lipid phenotype. Clin Sci (Lond) 119:265–272

DOI

4
Charman M, Kennedy BE, Osborne N, Karten B (2010) MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein. J Lipid Res 51:1023–1034

DOI

5
Holtta-Vuori M, Alpy F, Tanhaunapaa K, Jokitalo E, Mutka AL, Ikonen E (2005) MLN64 is involved in actin-mediated dynamics of late endocytic organelles. Mol Biol Cell 16:3873–3886

DOI

6
Kijlstra A, Tian Y, Kelly ER, Berendschot TT (2012) Lutein: more than just a filter for blue light. Prog Retin Eye Res 31:303–315

DOI

7
Kishida T, Kostetskii I, Zhang Z, Martinez F, Liu P, Walkley SU, Dwyer NK, Blanchette-Mackie EJ, Radice GL, Strauss JF 3rd (2004) Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. J Biol Chem 279:19276–19285

DOI

8
Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Welling CL, LutJohann D, Johnson KD, Brunham LR, Verchere CB, Hayden MR (2012) Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation and impaired β-cell function. Diabetes 61:659–664

DOI

9
Li B, Vachali P, Frederick JM, Bernstein PS (2011) Identification of StARD3 as a lutein-binding protein in the macula of the primate retina. Biochemistry 50:2541–2549

DOI

10
Rutti S, Ehses JA, Sibler RA, Prazak R, Rohrer L, Georgopoulos S, Meier DT, Niclauss N, Berney T, Donath MY, von Eckardstein A (2009) Low- and high-density lipoproteins modulate function, apoptosis and proliferation of primary human and murine pancreatic beta-cells. Endocrinology 150:4521–4530

DOI

11
Soffientini U, Caridis A-M, Dolan S, Graham A (2014) Intracellular cholesterol transporters and modulation of hepatic lipid metabolism: implications for diabetic dyslipidaemia and steatosis. Biochim Biophys Acta 1841:1372–1382

DOI

12
Souza JC, Vanzela EC, Ribeiro RA, Rezende LF, de Oliveira CA, Carneiro EM, Oliveira HC, Boschero AC (2013) Cholesterol reduction ameliorates glucose-induced calcium handling and insulin secretion in islets from low-density lipoprotein receptor knockout mice. Biochim Biophys Acta 1831:769–775

DOI

13
Tsuchiya M, Hosaka M, Moriguchi T, Zhang S, Suda M, Yokota-Hashimoto H, Shinozuka K, Takeuchi T (2010) Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta cells. Endocrinology 151:4705–4716

DOI

14
van der Kant R, Zondervan I, Jansse L, Neefjes J (2013) Cholesterol-binding molecules MLN64 and ORP1L mark distinct late endosomes with transporters ABCA3 and NPC1. J Lipid Res 54:2153–2165

DOI

15
Zuniga-Hertz JP, Rebelato E, Kassan A, Khalifa AM, Ali SS, Patel HH, Abdulkader F (2015) Distinct pathways of cholesterol biosynthesis impact on insulin secretion. J Endocrinol 224: 75–84

DOI

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