Protein & Cell >

2016 , Vol. 7 >Issue 4: 300 - 304

DOI: https://doi.org/10.1007/s13238-016-0256-7

LETTER

Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride

  • Linlin Zhao 1 ,
  • Shuqing Wang 2 ,
  • Lingyu Du 1 ,
  • Jyoti Dev 3 ,
  • Liujuan Zhou 1 ,
  • Zhijun Liu 1 ,
  • James J. Chou , 1,3 ,
  • Bo OuYang , 1,4
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  • 1. National Center for Protein Science, State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China
  • 2. Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin 300070, China
  • 3. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
  • 4. Shanghai Science Research Center, Chinese Academy of Sciences, Shanghai 201204, China

Published date: 09 May 2016

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Cite this article

Linlin Zhao , Shuqing Wang , Lingyu Du , Jyoti Dev , Liujuan Zhou , Zhijun Liu , James J. Chou , Bo OuYang . Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride[J]. Protein & Cell, 2016 , 7(4) : 300 -304 . DOI: 10.1007/s13238-016-0256-7

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Cook GA, Dawson LA, Tian Y, Opella SJ (2013) Three-dimensional structure and interaction studies of hepatitis C virus p7 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine by solution nuclear magnetic resonance. Biochemistry 52:5295–5303

DOI

2
DassaultSystèmesBIOVIA (2015) Discovery studio modeling environment. Dassault Systèmes, San Diego

3
Dev J, Bruschweiler S, Ouyang B, Chou JJ (2015) Transverse relaxation dispersion of the p7 membrane channel from hepatitis C virus reveals conformational breathing. J Biomol NMR 61:369–378

DOI

4
Foster TL, Verow M, Wozniak AL, Bentham MJ, Thompson J, Atkins E, Weinman SA, Fishwick C, Foster R, Harris M (2011) Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel. Hepatology 54:79–90

DOI

5
Foster TL, Thompson GS, Kalverda AP, Kankanala J, Bentham M, Wetherill LF, Thompson J, Barker AM, Clarke D, Noerenberg M (2014) Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release. Hepatology 59:408–422

DOI

6
Griffin SD, Beales LP, Clarke DS, Worsfold O, Evans SD, Jaeger J, Harris MP, Rowlands DJ (2003) The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine. FEBS Lett 535:34–38

DOI

7
Griffin S, Stgelais C, Owsianka AM, Patel AH, Rowlands D, Harris M (2008) Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel. Hepatology 48:1779–1790

DOI

8
Lauer GM, Walker BD (2001) Hepatitis C virus infection. N Engl J Med 345:41–52

DOI

9
Li H, Atkins E, Bruckner J, McArdle S, Qiu WC, Thomassen LV, Scott J, Shuhart MC, Livingston S, Townshend-Bulson L (2012) Genetic and functional heterogeneity of the hepatitis C virus p7 ion channel during natural chronic infection. Virology 423:30–37

DOI

10
Luscombe CA, Huang Z, Murray MG, Miller M, Wilkinson J, Ewart GD (2010) A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues. Antiviral Res 86:144–153

DOI

11
Moradpour D, Penin F (2013) Hepatitis C virus proteins: from structure to function. Curr Top Microbiol Immunol 369:113–142

DOI

12
OuYang B, Xie S, Berardi MJ, Zhao X, Dev J, Yu W, Sun B, Chou JJ (2013) Unusual architecture of the p7 channel from hepatitis C virus. Nature 498:521–525

DOI

13
Pavlovic D, Fischer W, Hussey M, Durantel D, Durantel S, Branza-Nichita N, Woodhouse S, Dwek RA, Zitzmann N (2005) Long alkylchain iminosugars block the HCV p7 ion channel. Adv Exp Med Biol 564:3–4

DOI

14
Pielak RM, Oxenoid K, Chou JJ (2011) Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses. Structure 19:1655–1663.

DOI

15
Premkumar A, Wilson L, Ewart GD, Gage PW (2004) Cationselective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride. FEBS Lett 557:99–103

DOI

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