Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride

References

[1] Cook GA, Dawson LA, Tian Y, Opella SJ (2013) Three-dimensional structure and interaction studies of hepatitis C virus p7 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine by solution nuclear magnetic resonance. Biochemistry 52:5295–5303

[2] DassaultSystèmesBIOVIA (2015) Discovery studio modeling environment. Dassault Systèmes, San Diego

[3] Dev J, Bruschweiler S, Ouyang B, Chou JJ (2015) Transverse relaxation dispersion of the p7 membrane channel from hepatitis C virus reveals conformational breathing. J Biomol NMR 61:369–378

[4] Foster TL, Verow M, Wozniak AL, Bentham MJ, Thompson J, Atkins E, Weinman SA, Fishwick C, Foster R, Harris M (2011) Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel. Hepatology 54:79–90

[5] Foster TL, Thompson GS, Kalverda AP, Kankanala J, Bentham M, Wetherill LF, Thompson J, Barker AM, Clarke D, Noerenberg M (2014) Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release. Hepatology 59:408–422

[6] Griffin SD, Beales LP, Clarke DS, Worsfold O, Evans SD, Jaeger J, Harris MP, Rowlands DJ (2003) The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine. FEBS Lett 535:34–38

[7] Griffin S, Stgelais C, Owsianka AM, Patel AH, Rowlands D, Harris M (2008) Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel. Hepatology 48:1779–1790

[8] Lauer GM, Walker BD (2001) Hepatitis C virus infection. N Engl J Med 345:41–52

[9] Li H, Atkins E, Bruckner J, McArdle S, Qiu WC, Thomassen LV, Scott J, Shuhart MC, Livingston S, Townshend-Bulson L (2012) Genetic and functional heterogeneity of the hepatitis C virus p7 ion channel during natural chronic infection. Virology 423:30–37

[10] Luscombe CA, Huang Z, Murray MG, Miller M, Wilkinson J, Ewart GD (2010) A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues. Antiviral Res 86:144–153

[11] Moradpour D, Penin F (2013) Hepatitis C virus proteins: from structure to function. Curr Top Microbiol Immunol 369:113–142

[12] OuYang B, Xie S, Berardi MJ, Zhao X, Dev J, Yu W, Sun B, Chou JJ (2013) Unusual architecture of the p7 channel from hepatitis C virus. Nature 498:521–525

[13] Pavlovic D, Fischer W, Hussey M, Durantel D, Durantel S, Branza-Nichita N, Woodhouse S, Dwek RA, Zitzmann N (2005) Long alkylchain iminosugars block the HCV p7 ion channel. Adv Exp Med Biol 564:3–4

[14] Pielak RM, Oxenoid K, Chou JJ (2011) Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses. Structure 19:1655–1663.

[15] Premkumar A, Wilson L, Ewart GD, Gage PW (2004) Cationselective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride. FEBS Lett 557:99–103

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2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.