RESEARCH HIGHLIGHT

Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos

  • Si Wang 1 ,
  • Fei Yi , 2 ,
  • Jing Qu , 3
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  • 1. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
  • 2. Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
  • 3. State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

Published date: 27 Jul 2015

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes fused with patient cells. This fascinating progression may encourage the development of novel therapy for human maternally inherent mitochondrial diseases.

Cite this article

Si Wang , Fei Yi , Jing Qu . Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos[J]. Protein & Cell, 2015 , 6(7) : 472 -475 . DOI: 10.1007/s13238-015-0177-x

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