LSY-2 is essential for maintaining the germ-soma distinction in C. elegans
Received date: 02 Feb 2015
Accepted date: 14 May 2015
Published date: 05 Aug 2015
Copyright
The mechanisms that specify and maintain the characteristics of germ cells during animal development are poorly understood. In this study, we demonstrated that loss of function of the zinc-finger gene lsy-2 results in various somatic cells adopting germ cells characteristics, including expression of germline-specific P granules, enhanced RNAi activity and transgene silencing. The soma to germ transformation in lsy-2 mutants requires the activities of multiple chromatin remodeling complexes, including the MES-4 complex and the ISW-1 complex. The distinct germline-specific features in somatic cells and the gene expression profile indicate that LSY-2 acts in the Mec complex in this process. Our study demonstrated that lsy-2 functions in the maintenance of the soma-germ distinction.
Key words： P granules; soma; lsy-2; C. elegans
Long Lin , Yuping Li , Libo Yan , Gangming Zhang , Yu Zhao , Hong Zhang . LSY-2 is essential for maintaining the germ-soma distinction in C. elegans[J]. Protein & Cell, 2015 , 6(8) : 599 -609 . DOI: 10.1007/s13238-015-0173-1
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