Atg7 in development and disease: panacea or Pandora’s Box?
Received date: 23 Jun 2015
Accepted date: 13 Jul 2015
Published date: 22 Oct 2015
Copyright
Macroautophagy is an evolutionarily conserved intracellular degradation system used by life ranging from yeasts to mammals. The core autophagic machinery is composed of ATG (autophagy-related) protein constituents. One particular member of the ATG protein family, Atg7, has been the focus of recent research. Atg7 acts as an E1-like activating enzyme facilitating both microtubule-associated protein light chain 3 (LC3)-phosphatidylethanolamine and ATG12 conjugation. Thus, Atg7 stands at the hub of these two ubiquitin-like systems involving LC3 and Atg12 in autophagic vesicle expansion. In this review, I focus on the pleiotropic function of Atg7 in development, maintenance of health, and alternations of such control in disease.
Key words: autophagy; Atg7; mouse model; development; disease
Jianhua Xiong . Atg7 in development and disease: panacea or Pandora’s Box?[J]. Protein & Cell, 2015 , 6(10) : 722 -734 . DOI: 10.1007/s13238-015-0195-8
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