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Structural basis of PKM2 regulation

  • Weiwei Yang
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  • Key Laboratory of System Biology and Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

Received date: 01 Jan 2015

Accepted date: 01 Jan 2015

Published date: 13 Apr 2015

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cite this article

Weiwei Yang . Structural basis of PKM2 regulation[J]. Protein & Cell, 2015 , 6(4) : 238 -240 . DOI: 10.1007/s13238-015-0146-4

1
Altenberg B, Greulich KO (2004) Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics84: 1014-1020

DOI

2
Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A (2012) Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nat Chem Biol8: 839-847

DOI

3
Chaneton B, Gottlieb E (2012) Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer. Trends Biochem Sci37: 309-316

DOI

4
Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC (2008) The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature452: 230-233

DOI

5
Corcoran E, Phelan JJ, Fottrell PF (1976) Purification and properties of pyruvate kinase from human lung. Biochim Biophys Acta446: 96-104

DOI

6
Dombrauckas JD, Santarsiero BD, Mesecar AD (2005) Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry44: 9417-9429

DOI

7
Gao X, Wang H, Yang JJ, Liu X, Liu ZR (2012) Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Mol Cell45: 598-609

DOI

8
Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer4: 891-899

DOI

9
Gui DY, Lewis CA, Vander Heiden MG (2013) Allosteric regulation of PKM2 allows cellular adaptation to different physiological states. Sci Signal6: pe7

DOI

10
Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ (2009) Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Science Signaling2: ra73

DOI

11
Iqbal MA, Siddiqui FA, Chaman N, Gupta V, Kumar B, Gopinath P, Bamezai RN (2014) Missense mutations in pyruvate kinase M2 promote cancer metabolism, oxidative endurance, anchorage independence, and tumor growth in a dominant negative manner. J Biol Chem289: 8098-8105

DOI

12
Kim JW, Dang CV (2006) Cancer’s molecular sweet tooth and the Warburg effect. Cancer Res66: 8927-8930

DOI

13
Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Liu Y, Li Z, Xu Y (2011) Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Mol Cell42: 719-730

DOI

14
Morgan HP, McNae IW, Nowicki MW, Hannaert V, Michels PA, Fothergill-Gilmore LA, Walkinshaw MD (2010) Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model. J Biol Chem285: 12892-12898

DOI

15
Morgan HP, O’Reilly FJ, Wear MA, O’Neill JR, Fothergill-Gilmore LA, Hupp T, Walkinshaw MD (2013) M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation. Proc Natl Acad Sci USA: 5881-5886

DOI

16
Noguchi T, Yamada K, Inoue H, Matsuda T, Tanaka T (1987) The Land R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters. J Biol Chem262: 14366-14371

17
Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science324: 1029-1033

DOI

18
Wang P, Sun C, Zhu T, Xu Y (2015) Structural insight into mechanisms for dynamic regulation of PKM2. Protein Cell.

DOI

19
Warburg O (1956) On the origin of cancer cells. Science123: 309-314

DOI

20
Yang W, Lu Z (2013) Regulation and function of pyruvate kinase M2 in cancer. Cancer Lett339: 153-158

DOI

21
Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z (2011) Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature480: 118-122

DOI

22
Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K (2012a) EGFR-induced and PKCepsilon monoubiquitylation- dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell48: 771-784

DOI

23
Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z (2012b) PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell150: 685-696

DOI

24
Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z (2012c) ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol14: 1295-1304

DOI

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