Protein & Cell >

2010 , Vol. 1 >Issue 7: 621 - 626

DOI: https://doi.org/10.1007/s13238-010-0073-3

Research articles

Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites

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  • 1.CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China.; 2.CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100101, China.；Graduate University of Chinese Academy of Sciences, Beijing 100049, China.;

Published date: 01 Jul 2010

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Abstract

Synthetic biology aims to design and build new biological systems with desirable properties, providing the foundation for the biosynthesis of secondary metabolites. The most prominent representation of synthetic biology has been used in microbial engineering by recombinant DNA technology. However, there are advantages of using a deleted host, and therefore an increasing number of biotechnology studies follow similar strategies to dissect cellular networks and construct genome-reduced microbes. This review will give an overview of the strategies used for constructing and engineering reduced-genome factories by synthetic biology to improve production of secondary metabolites.

Key words： synthetic biology; reduced-genome; secondary metabolite

Cite this article

Hong Gao, Elizabeth Ashforth, Lixin Zhang, Ying Zhuo, . Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites[J]. Protein & Cell, 2010 , 1(7) : 621 -626 . DOI: 10.1007/s13238-010-0073-3

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