DHA, a potentially therapeutic lipid for myocardial infarction

Chenglu Xiao , Jing-Wei Xiong

Protein Cell ›› 2026, Vol. 17 ›› Issue (1) : 1 -4.

PDF (178KB)
Protein Cell ›› 2026, Vol. 17 ›› Issue (1) :1 -4. DOI: 10.1093/procel/pwaf073
Highlight
DHA, a potentially therapeutic lipid for myocardial infarction
Author information +
History +
PDF (178KB)

Cite this article

Download citation ▾
Chenglu Xiao, Jing-Wei Xiong. DHA, a potentially therapeutic lipid for myocardial infarction. Protein Cell, 2026, 17(1): 1-4 DOI:10.1093/procel/pwaf073

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Brown NF , Weis BC , Husti JE et al. Mitochondrial carnitine palmitoyltransferase Ⅰ isoform switching in the developing rat heart. J Biol Chem 1995; 270: 8952– 8957.

[2]

Chen X , Wu H , Liu Y et al. Metabolic reprogramming: a byproduct or a driver of cardiomyocyte proliferation. Circulation 2024; 149: 1598– 1610.

[3]

Cheng YY , Gregorich Z , Prajnamitra RP et al. Metabolic changes associated with cardiomyocyte dedifferentiation enable adult mammalian cardiac regeneration. Circulation 2022; 146: 1950– 1967.

[4]

Cheng X , Ju J , Huang W et al. cpt1b regulates cardiomyocyte proliferation through modulation of glutamine synthetase in zebrafish. J Cardiovasc Dev Dis 2024; 11: 344.

[5]

Du JY , Zheng LX , Gao P et al. A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Cell Stem Cell 2022; 29: 545– 558.e13.

[6]

Ebrahimi B. Cardiac progenitor reprogramming for heart regeneration. Cell Regen 2018; 7: 1– 6.

[7]

Fajardo VM , Feng I , Chen BY et al. GLUT1 overexpression enhances glucose metabolism and promotes neonatal heart regeneration. Sci Rep 2021; 11: 8669.

[8]

Hashmi S , Ahmad HR. Molecular switch model for cardiomyocyte proliferation. Cell Regen 2019; 8: 12– 20.

[9]

He L , Kim T , Long Q et al. Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity. Circulation 2012; 126: 1705– 1716.

[10]

Hume RD , Kanagalingam S , Deshmukh T et al. Tropoelastin improves post-infarct cardiac function. Circ Res 2023; 132: 72– 86.

[11]

Jopling C , Sleep E , Raya M et al. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 2010; 464: 606– 609.

[12]

Kikuchi K , Holdway JE , Werdich AA et al. Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes. Nature 2010; 464: 601– 605.

[13]

Li X , Wu F , Gunther S et al. Inhibition of fatty acid oxidation enables heart regeneration in adult mice. Nature 2023; 622: 619– 626.

[14]

Lionetti V , Linke A , Chandler MP et al. Carnitine palmitoyl transferase-Ⅰ inhibition prevents ventricular remodeling and delays decompensation in pacing-induced heart failure. Cardiovasc Res 2005; 66: 454– 461.

[15]

Nakada Y , Canseco DC , Thet S et al. Hypoxia induces heart regeneration in adult mice. Nature 2017; 541: 222– 227.

[16]

Porrello ER , Mahmoud AI , Simpson E et al. Transient regenerative potential of the neonatal mouse heart. Science 2011; 331: 1078– 1080.

[17]

Poss KD , Wilson LG , Keating MT. Heart regeneration in zebrafish. Science 2002; 298: 2188– 2190.

[18]

Puente BN , Kimura W , Muralidhar SA et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 2014; 157: 565– 579.

[19]

Schmidt-Schweda S , Holubarsch C. First clinical trial with etomoxir in patients with chronic congestive heart failure. Clin Sci (Lond) 2000; 99: 27– 35.

[20]

Schwarzer M , Faerber G , Rueckauer T et al. The metabolic modulators, Etomoxir and NVP-LAB121, fail to reverse pressure overload induced heart failure in vivo. Basic Res Cardiol 2009; 104: 547– 557.

[21]

Tang L , Shi Y , Liao Q et al. Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylation-mediated p38 MAPK phosphorylation. Acta Pharm Sin B 2025; 15: 256– 277.

[22]

Wang J , Liu SJ , Heallen T et al. The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration. Nat Rev Cardiol 2018; 15: 672– 684.

[23]

Zhao Y , Lv H , Yu C et al. Systemic inhibition of mitochondrial fatty acid β-oxidation impedes zebrafish ventricle regeneration. Biochim Biophys Acta Mol Basis Dis 2024; 1870: 167442.

RIGHTS & PERMISSIONS

© The Author(s) 2025. Published by Oxford University Press on behalf of Higher Education Press.

PDF (178KB)

105

Accesses

0

Citation

Detail

Sections
Recommended

/