Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer

Yaxin Wang , Qinqin Liang , Shengjian Liang , Yuanyue Shan , Sai Shi , Xiaoyu Zhou , Ziyu Wang , Zhili Xu , Duanqing Pei , Mingfeng Zhang , Zhiyong Lou , Binghong Xu , Sheng Ye

Protein Cell ›› 2025, Vol. 16 ›› Issue (11) : 991 -996.

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Protein Cell ›› 2025, Vol. 16 ›› Issue (11) : 991 -996. DOI: 10.1093/procel/pwaf044
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Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer

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Yaxin Wang, Qinqin Liang, Shengjian Liang, Yuanyue Shan, Sai Shi, Xiaoyu Zhou, Ziyu Wang, Zhili Xu, Duanqing Pei, Mingfeng Zhang, Zhiyong Lou, Binghong Xu, Sheng Ye. Bardoxolone methyl blocks the efflux of Zn2+ by targeting hZnT1 to inhibit the proliferation and metastasis of cervical cancer. Protein Cell, 2025, 16(11): 991-996 DOI:10.1093/procel/pwaf044

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Xue J , Xie T , Zeng W et al. Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations. Elife 2020; 9: e58823.

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