Integrative transcriptomic and epigenomic analysis identifies BCL6B as a novel regulator of human pluripotent stem cell to endothelial differentiation

Yonglin Zhu; Jinyang Liu; Jia Wang; Shuangyuan Ding; Hui Qiu; Xia Chen; Jianying Guo; Peiliang Wang; Xingwu Zhang; Fengzhi Zhang; Rujin Huang; Fuyu Duan; Lin Wang; Jie Na

doi:10.1093/procel/pwaf039

Protein Cell ›› 2025, Vol. 16 ›› Issue (11) : 985 -990. DOI: 10.1093/procel/pwaf039

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Integrative transcriptomic and epigenomic analysis identifies BCL6B as a novel regulator of human pluripotent stem cell to endothelial differentiation

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¹. Center for Regeneration, Aging and Chronic Diseases, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China

². SXMU-Tsinghua Collaborative Center for Frontier Medicine, Shanxi Medical University, Taiyuan 030001, China

³. School of Life Sciences, Tsinghua University, Beijing 100084, China

⁴. Center for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, Beijing 100191, China

⁵. Central laboratory, The First Hospital of Tsinghua University, Beijing 100016, China

⁶. CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

⁷. Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen 518017, China

⁸. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

⁹. State Key Laboratory for Complex, Severe and Rare Diseases, Tsinghua University, Beijing 100084, China

jie.na@tsinghua.edu.cn (J. Na)

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Yonglin Zhu, Jinyang Liu, Jia Wang, Shuangyuan Ding, Hui Qiu, Xia Chen, Jianying Guo, Peiliang Wang, Xingwu Zhang, Fengzhi Zhang, Rujin Huang, Fuyu Duan, Lin Wang, Jie Na. Integrative transcriptomic and epigenomic analysis identifies BCL6B as a novel regulator of human pluripotent stem cell to endothelial differentiation. Protein Cell, 2025, 16(11): 985-990 DOI:10.1093/procel/pwaf039

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