African spiny mice show resistance to DMBA/TPA-induced squamous carcinogenesis with distinct benign tumor profile

Fathima Athar; Francesco Morandini; Iqra Fatima; Isabella Silvestri; Sei Joong Kim; Minseon Lee; Xiaoyan Liao; Andrei Sharov; Vladimir Botchkarev; Andrei Seluanov; Vera Gorbunova

doi:10.1093/procel/pwaf024

Protein Cell ›› 2025, Vol. 16 ›› Issue (10) : 896 -904. DOI: 10.1093/procel/pwaf024

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African spiny mice show resistance to DMBA/TPA-induced squamous carcinogenesis with distinct benign tumor profile

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Fathima Athar, Francesco Morandini, Iqra Fatima, Isabella Silvestri, Sei Joong Kim, Minseon Lee, Xiaoyan Liao, Andrei Sharov, Vladimir Botchkarev, Andrei Seluanov, Vera Gorbunova. African spiny mice show resistance to DMBA/TPA-induced squamous carcinogenesis with distinct benign tumor profile. Protein Cell, 2025, 16(10): 896-904 DOI:10.1093/procel/pwaf024

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References

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[1]	Andrew White LD , Hsu C-H , Yang Y . Skin regeneration underlies cancer resistance in Acomys. Research Square 2024.

[2]	Clevers H . Wnt/β-catenin signaling in development and disease. Cell 2006; 127: 469- 480.

[3]	Diao Y , Rahman MF , Vyatkin Y et al. Identification of novel GLI1 target genes and regulatory circuits in human cancer cells. Mol Oncol 2018; 12: 1718- 1734.

[4]	Doumpas N , Lampart F , Robinson MD et al. TCF/LEF dependent and independent transcriptional regulation of Wnt/β-catenin target genes. EMBO J 2019; 38: e98873.

[5]	Hao YH , Lafita-Navarro MC , Zacharias L et al. Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation. Cell Commun Signal 2019; 17: 129.

[6]	Rangarajan A , Hong SJ , Gifford A et al. Species- and cell type-specific requirements for cellular transformation. Cancer Cell 2004; 6: 171- 183.

[7]	Sandoval AGW , Maden M , Bates LE et al. Tumor suppressors inhibit reprogramming of African spiny mouse (Acomys) fibroblasts to induced pluripotent stem cells. Wellcome Open Res 2022; 7: 215.

[8]	Seifert AW , Kiama SG , Seifert MG et al. Skin shedding and tissue regeneration in African spiny mice (Acomys). Nature 2012; 489: 561- 565.

[9]	Su Z , Song J , Wang Z et al. Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. Proc Natl Acad Sci USA 2018; 115: E7522- E7531.

[10]	Takeda H , Lyle S , Lazar AJ et al. Human sebaceous tumors harbor inactivating mutations in LEF1. Nat Med 2006; 12: 395- 397.

[11]	Tian X , Azpurua J , Hine C et al. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature 2013; 499: 346- 349.

[12]	Tian X , Doerig K , Park R et al. Evolution of telomere maintenance and tumour suppressor mechanisms across mammals. Philos Trans R Soc Lond B Biol Sci 2018; 373: 20160443.

[13]	Tomasso A , Disela V , Longaker MT et al. Marvels of spiny mouse regeneration: cellular players and their interactions in restoring tissue architecture in mammals. Curr Opin Genet Dev 2024; 87: 102228.

[14]	Vitorino M , Pinheiro GG , Araujo IM et al. Resistance to carcinogenesis in the African Spiny Mouse (Acomys) correlates with upregulation of tumor suppressor genes. bioRxiv 2024.

[15]	Zhao Y , Seluanov A , Gorbunova V . Revelations about aging and disease from unconventional vertebrate model organisms. Annu Rev Genet 2021; 55: 135- 159.