Mechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex

Yubin Tang , Yaoyao Han , Zhenpeng Guo , Ying Li , Xinyu Gong , Yuchao Zhang , Haobo Liu , Xindi Zhou , Daichao Xu , Yixiao Zhang , Lifeng Pan

Protein Cell ›› 2025, Vol. 16 ›› Issue (8) : 739 -744.

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Protein Cell ›› 2025, Vol. 16 ›› Issue (8) : 739 -744. DOI: 10.1093/procel/pwaf018
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Mechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex

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Yubin Tang, Yaoyao Han, Zhenpeng Guo, Ying Li, Xinyu Gong, Yuchao Zhang, Haobo Liu, Xindi Zhou, Daichao Xu, Yixiao Zhang, Lifeng Pan. Mechanistic insights into the GEF activity of the human MON1A/CCZ1/C18orf8 complex. Protein Cell, 2025, 16(8): 739-744 DOI:10.1093/procel/pwaf018

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References

[1]

Chua CE, Gan BQ, Tang BL. Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation. Cell Mol Life Sci 2011;68:3349–3358.

[2]

Gutierrez MG, Munafo DB, Beron W et al. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci 2004;117:2687–2697.

[3]

Herrmann E, Schafer JH, Wilmes S et al. Structure of the metazoan Rab7 GEF complex Mon1-Ccz1-Bulli. Proc Natl Acad Sci USA 2023;120:e2301908120.

[4]

Kiontke S, Langemeyer L, Kuhlee A et al. Architecture and mechanism of the late endosomal Rab7-like Ypt7 guanine nucleotide exchange factor complex Mon1-Ccz1. Nat Commun 2017;8:14034.

[5]

Nordmann M, Cabrera M, Perz A et al. The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 Homolog Ypt7. Curr Biol 2010;20:1654–1659.

[6]

Stroupe C. This is the end: regulation of Rab7 nucleotide binding in endolysosomal trafficking and autophagy. Front Cell Dev Biol 2018;6:129.

[7]

Vaites LP, Paulo JA, Huttlin EL et al. Systematic analysis of human cells lacking ATG8 proteins uncovers roles for GABARAPs and the CCZ1/MON1 regulator C18orf8/RMC1 in macroautophagic and selective autophagic flux. Mol Cell Biol 2018;38:e00392–e00317.

[8]

Yamano K, Wang C, Sarraf SA et al. Endosomal Rab cycles regulate Parkin-mediated mitophagy. Elife 2018;7:e31326.

[9]

Yong X, Jia G, Liu Z et al. Cryo-EM structure of the Mon1-Ccz1-RMC1 complex reveals molecular basis of metazoan RAB7A activation. Proc Natl Acad Sci USA 2023;120:e2301725120

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The Author(s) 2025. Published by Oxford University Press on behalf of Higher Education Press.

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