Pasteurized Akkermansia muciniphila promotes GP2 expression in microfold cells and facilitates Salmonella infection

References

[1] Beloqui A , Brayden DJ , Artursson P et al. A human intestinal M-cell-like model for investigating particle, antigen and microorganism translocation. Nat Protoc 2017; 12: 1387- 1399.

[2] Bian X , Wu W , Yang L et al. Administration of Akkermansia muciniphila Ameliorates dextran sulfate sodium-induced ulcerative colitis in mice. Front Microbiol 2019; 10: 2259.

[3] Cani PD , Depommier C , Derrien M et al. Akkermansia muciniphila:paradigm for next-generation beneficial microorganisms. Nat Rev Gastroenterol Hepatol 2022; 19: 625- 637.

[4] Chen Z , Qian X , Chen S et al. Akkermansia muciniphila enhances the antitumor effect of cisplatin in lewis lung cancer mice. J Immunol Res 2020; 2020: 2969287.

[5] Collins JW , Keeney KM , Crepin VF et al. Citrobacter rodentium:infection, inflammation and the microbiota. Nat Rev Microbiol 2014; 12: 612- 623.

[6] Dey P , Ray Chaudhuri S . The opportunistic nature of gut commensal microbiota. Crit Rev Microbiol 2023; 49: 739- 763.

[7] Elzinga J , Narimatsu Y , de Haan N et al. Binding of Akkermansia muciniphila to mucin is O-glycan specific. Nat Commun 2024; 15: 4582.

[8] Everard A , Belzer C , Geurts L et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A 2013; 110: 9066- 9071.

[9] Fang X , Li FJ , Hong DJ . Potential role of Akkermansia muciniphila in Parkinson's disease and other neurological/autoimmune diseases. Curr Med Sci 2021; 41: 1172- 1177.

[10] Fujimura Y , Takeda M , Ikai H et al. The role of M cells of human nasopharyngeal lymphoid tissue in influenza virus sampling. Virchows Arch 2004; 444: 36- 42.

[11] Fukuda S , Hase K , Ohno H . Application of a mouse ligated Peyer's patch intestinal loop assay to evaluate bacterial uptake by M cells. J Vis Exp 2011; 58: 3225.

[12] Galan JE . Salmonella Typhimurium and inflammation:a pathogen-centric affair. Nat Rev Microbiol 2021; 19: 716- 725.

[13] Gonzalez-Hernandez MB , Liu T , Payne HC et al. Efficient norovirus and reovirus replication in the mouse intestine requires microfold (M) cells. J Virol 2014; 88: 6934- 6943.

[14] Hase K , Kawano K , Nochi T et al. Uptake through glycoprotein 2 of FimH⁺ bacteria by M cells initiates mucosal immune response. Nature 2009; 462: 226- 230.

[15] Khan I , Bai Y , Zha L et al. Mechanism of the gut microbiota colonization resistance and enteric pathogen infection. Front Cell Infect Microbiol 2021; 11: 716299.

[16] Kobayashi N , Takahashi D , Takano S et al. The roles of Peyer's patches and microfold cells in the gut immune system:relevance to autoimmune diseases. Front Immunol 2019; 10: 2345.

[17] Li L , Li M , Chen Y et al. Function and therapeutic prospects of next-generation probiotic Akkermansia muciniphila in infectious diseases. Front Microbiol 2024; 15: 1354447.

[18] Luna Velez MV , Neikes HK , Snabel RR et al. ONECUT2 regulates RANKL-dependent enterocyte and microfold cell differentiation in the small intestine; a multi-omics study. Nucleic Acids Res 2023; 51: 1277- 1296.

[19] Pickard JM , Zeng MY , Caruso R et al. Gut microbiota:role in pathogen colonization, immune responses, and inflammatory disease. Immunol Rev 2017; 279: 70- 89.

[20] Shuoker B , Pichler MJ , Jin C et al. Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria. Nat Commun 2023; 14: 1833.

[21] Vidal-Martinez G , Chin B , Camarillo C et al. A Pilot Microbiota Study in Parkinson's disease patients versus control subjects, and effects of FTY720 and FTY720-mitoxy therapies in Parkinsonian and multiple system atrophy mouse models. J Parkinsons Dis 2020; 10: 185- 192.

[22] Yoo JY , Groer M , Dutra SVO et al. Gut microbiota and immune system interactions. Microorganisms 2020; 8: 2046.

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The Author(s). Published by Oxford University Press on behalf of Higher Education Press.