Step-wise organization of genomic nuclear speckle-associated domains during mammalian embryonic development

Mengyao Kang; Tongzhen Zhang; Chao Ning; Yibing Bao; Zhenbo Liu; Lei Gao; Linghui Luan; Chao Wang; Jiang Liu; Yuwen Ke

doi:10.1093/procel/pwaf015

Protein Cell ›› 2025, Vol. 16 ›› Issue (9) :815 -821. DOI: 10.1093/procel/pwaf015

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Step-wise organization of genomic nuclear speckle-associated domains during mammalian embryonic development

Mengyao Kang ¹^,⁴^,⁷
, Tongzhen Zhang ¹^,⁴
, Chao Ning ⁴^,⁵
, Yibing Bao ²^,³
, Zhenbo Liu ¹
, Lei Gao ¹
, Linghui Luan ¹^,⁴
, Chao Wang ²^,³
, Jiang Liu ¹^,⁴^,⁶
, Yuwen Ke ²^,³

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¹. Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

². Frontiers Science Center for Molecular Design Breeding (MOE), China Agricultural University, Beijing 100193, China

³. State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Beijing 100193, China

⁴. College of Life Sciences, University of the Chinese Academy of Sciences, Beijing 100049, China

⁵. National Laboratory of Biomacro-molecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

⁶. School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China

⁷. Laboratory of Bone Tissue Engineering, Beijing Laboratory of Biomedical Materials, National Center for Orthopaedics, Beijing Research Institute of Traumatology and Orthopaedics, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China

liujiang@ibp.ac.cn (J. Liu)

keyw@cau.edu.cn (Y. Ke)

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Mengyao Kang, Tongzhen Zhang, Chao Ning, Yibing Bao, Zhenbo Liu, Lei Gao, Linghui Luan, Chao Wang, Jiang Liu, Yuwen Ke. Step-wise organization of genomic nuclear speckle-associated domains during mammalian embryonic development. Protein Cell, 2025, 16(9): 815-821 DOI:10.1093/procel/pwaf015

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