FOXO3-engineered human mesenchymal stem cells efficiently enhance post-ischemic stroke functional rehabilitation

Fangshuo Zheng; Jinghui Lei; Zan He; Taixin Ning; Shuhui Sun; Yusheng Cai; Qian Zhao; Shuai Ma; Weiqi Zhang; Jing Qu; Guang-Hui Liu; Si Wang

doi:10.1093/procel/pwaf004

Protein Cell ›› 2025, Vol. 16 ›› Issue (5) : 365 -373. DOI: 10.1093/procel/pwaf004

LETTER

FOXO3-engineered human mesenchymal stem cells efficiently enhance post-ischemic stroke functional rehabilitation

Fangshuo Zheng ¹^,²
, Jinghui Lei ³^,⁴
, Zan He ³^,⁴
, Taixin Ning ³^,⁴
, Shuhui Sun ⁵
, Yusheng Cai ¹^,⁶
, Qian Zhao ³^,⁴
, Shuai Ma ¹^,⁶^,⁷
, Weiqi Zhang ⁷^,⁸^,⁹^,¹⁰^,¹¹^,¹²
, Jing Qu ¹^,⁵^,⁶^,⁷^,⁸^,^†
, Guang-Hui Liu ¹^,³^,⁶^,⁷^,⁸^,^†
, Si Wang ³^,⁴^,⁷^,^†

Author information +

¹. Key Laboratory of Organ Regeneration and Reconstruction, State Key Laboratory of Membrane Biology, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

². Department of Neurology, The Fifth People’s Hospital of Chongqing, Chongqing 400062, China

³. Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

⁴. Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

⁵. Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

⁶. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

⁷. Aging Biomarker Consortium, Beijing 100101, China

⁸. University of Chinese Academy of Sciences, Beijing 100049, China

⁹. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

¹⁰. China National Center for Bioinformation, Beijing 100101, China

¹¹. Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China

¹². Sino-Danish Center for Education and Research, Beijing 101408, China

qujing@ioz.ac.cn

ghliu@ioz.ac.cn

wangsi@xwh.ccmu.edu.cn

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Fangshuo Zheng, Jinghui Lei, Zan He, Taixin Ning, Shuhui Sun, Yusheng Cai, Qian Zhao, Shuai Ma, Weiqi Zhang, Jing Qu, Guang-Hui Liu, Si Wang. FOXO3-engineered human mesenchymal stem cells efficiently enhance post-ischemic stroke functional rehabilitation. Protein Cell, 2025, 16(5): 365-373 DOI:10.1093/procel/pwaf004

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