A minimally invasive, fast on/off “odorgenetic” method to manipulate physiology

Yanqiong Wu; Xueqin Xu; Shanchun Su; Zeyong Yang; Xincai Hao; Wei Lu; Jianghong He; Juntao Hu; Xiaohui Li; Hong Yu; Xiuqin Yu; Yangqiao Xiao; Shuangshuang Lu; Linhan Wang; Wei Tian; Hongbing Xiang; Gang Cao; Wen Jun Tu; Changbin Ke

doi:10.1093/procel/pwae072

Protein Cell ›› 2025, Vol. 16 ›› Issue (7) : 615 -620. DOI: 10.1093/procel/pwae072

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A minimally invasive, fast on/off “odorgenetic” method to manipulate physiology

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Yanqiong Wu, Xueqin Xu, Shanchun Su, Zeyong Yang, Xincai Hao, Wei Lu, Jianghong He, Juntao Hu, Xiaohui Li, Hong Yu, Xiuqin Yu, Yangqiao Xiao, Shuangshuang Lu, Linhan Wang, Wei Tian, Hongbing Xiang, Gang Cao, Wen Jun Tu, Changbin Ke. A minimally invasive, fast on/off “odorgenetic” method to manipulate physiology. Protein Cell, 2025, 16(7): 615-620 DOI:10.1093/procel/pwae072

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References

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[1]	Avaliani N, Andersson M, Runegaard AH et al. DREADDs suppress seizure-like activity in a mouse model of pharmacoresistant epileptic brain tissue. Gene Ther 2016;23:760–766.

[2]	Becnel J, Johnson O, Majeed ZR et al. DREADDs in Drosophila: a pharmacogenetic approach for controlling behavior, neuronal signaling, and physiology in the fly. Cell Rep 2013;4:1049–1059.

[3]	Bernstein JG, Boyden ES. Optogenetic tools for analyzing the neural circuits of behavior. Trends Cogn Sci 2011;15:592–600.

[4]	Carter ME, Yizhar O, Chikahisa S et al. Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci 2010;13:1526–1533.

[5]	DasGupta S, Waddell S. Learned odor discrimination in Drosophila without combinatorial odor maps in the antennal lobe. Curr Biol 2008;18:1668–1674.

[6]	Gomez JL, Bonaventura J, Lesniak W et al. Chemogenetics revealed: DREADD occupancy and activation via converted clozapine. Science 2017;357:503–507.

[7]	Kätzel D, Nicholson E, Schorge S et al. Chemical-genetic attenuation of focal neocortical seizures. Nat Commun 2014;5:3847.

[8]	Lan EI, Dekishima Y, Chuang DS et al. Metabolic engineering of 2-pentanone synthesis in Escherichia coli. AIChE J 2013;59:3167–3175.

[9]	Madisen L, Mao T, Koch H et al. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat Neurosci 2012;15:793–802.

[10]	Magnus CJ, Lee PH, Bonaventura J et al. Ultrapotent chemogenetics for research and potential clinical applications. Science 2019;364:eaav5282.

[11]	Matveev MV, Erofeev AI, Terekhin SG et al. Implantable devices for optogenetic studies and stimulation of excitable tissue. St. Petersburg Polytech Univ J Phys Math 2015;1:264–271.

[12]	McCarthy AI, Wyman H, Palmer JK. Gas chromatographic identification of banana fruit volatiles. J Chromatogr Sci 1964;2:121–124.

[13]	Nichols AS, Luetje CW. Transmembrane segment 3 of Drosophila melanogaster odorant receptor subunit 85b contributes to ligand-receptor interactions. J Biol Chem 2010;285:11854–11862.

[14]	Raper J, Morrison RD, Daniels JS et al. Metabolism and distribution of clozapine-N-oxide: implications for nonhuman primate chemogenetics. ACS Chem Neurosci 2017;8:1570–1576.

[15]	Urban DJ, Roth BL. DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annu Rev Pharmacol Toxicol 2015;55:399–417.