Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis

Guixing Ma; Yingying Han; Wanze Tang; Bo Zhou; Litong Chen; Zhen Ding; Siyuan Cheng; Di Chen; Huiling Cao

doi:10.1093/procel/pwae066

Protein Cell ›› 2025, Vol. 16 ›› Issue (6) : 497 -502. DOI: 10.1093/procel/pwae066

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Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis

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Guixing Ma, Yingying Han, Wanze Tang, Bo Zhou, Litong Chen, Zhen Ding, Siyuan Cheng, Di Chen, Huiling Cao. Endothelial-to-Osteoblast Conversion maintains bone homeostasis through Kindlin-2/Piezo1/TGFβ/Runx2 axis. Protein Cell, 2025, 16(6): 497-502 DOI:10.1093/procel/pwae066

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References

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[1]	Bae C, Sachs F, Gottlieb PA. The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4. Biochemistry 2011;50:6295–6300.

[2]	Beltrao P, Albanèse V, Kenner LR et al. Systematic functional prioritization of protein posttranslational modifications. Cell 2012;150:413–425.

[3]	Cao J, Jin L, Yan ZQ et al. Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models. Nat Commun 2023;14:8461.

[4]	Dong Y, Chen Y, Ma G et al. The role of E3 ubiquitin ligases in bone homeostasis and related diseases. Acta Pharm Sin B 2023a;13:3963–3987.

[5]	Dong Y, Ma G, Hou X et al. Kindlin-2 controls angiogenesis through modulating Notch1 signaling. Cell Mol Life Sci 2023b;80:223.

[6]	Fu X, Zhou B, Yan Q et al. Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Signal Transduct Targ Ther 2020;5:297.

[7]	Kenswil KJG, Pisterzi P, Sanchez-Duffhues G et al. Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche fo rmation. Cell Stem Cell 2021;28:653–670.e11.

[8]	Kusumbe AP, Ramasamy SK, Adams RH. Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature 2014;507:323–328.

[9]	Li J, Hou B, Tumova S et al. Piezo1 integration of vascular architecture with physiological force. Nature 2014;515:279–282.

[10]	Lin SC, Lee YC, Yu G et al. Endothelial-to-osteoblast conversion generates osteoblastic metastasis of prostate cancer. Dev Cell 2017;41:467–480.e3.

[11]	Medici D, Shore EM, Lounev VY et al. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med 2010;16:1400–1406.

[12]	Syeda R, Xu J, Dubin AE et al. Chemical activation of the mechanotransduction channel Piezo1. elife 2015;4:e07369.

[13]	Takarada T, Nakazato R, Tsuchikane A et al. Genetic analysis of Runx2 function during intramembranous ossification. Development 2016;143:211–218.

[14]	Tang W, Ding Z, Gao H et al. Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice. Acta Pharm Sin B 2023;13:4535–4552.

[15]	Zhen G, Wen C, Jia X et al. Inhibition of TGF-beta signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med 2013;19:704–712.