The role of parkin in monkey

References

[1] Aarsland D, Batzu L, Halliday GM et al. Parkinson disease-associated cognitive impairment. Nat Rev Dis Primers 2021;7:47.

[2] Burbulla LF, Song P, Mazzulli JR et al. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease. Science 2017;357:1255–1261.

[3] Chen XS, Han R, Liu YT et al. Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation. Zool Res 2024;45:242–252.

[4] Fujiwara H, Hasegawa M, Dohmae N et al. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 2002;4:160–164.

[5] Gegg ME, Cooper JM, Chau KY et al. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 2010;19:4861–4870.

[6] Geisler S, Holmstrom KM, Skujat D et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010;12:119–131.

[7] Goldberg MS, Fleming SM, Palacino JJ et al. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem 2003;278:43628–43635.

[8] Han R, Wang Q, Xiong X et al. Deficiency of parkin causes neurodegeneration and accumulation of pathological alpha-synuclein in monkey models. J Clin Invest 2024;134:e179633.

[9] Kitada T, Asakawa S, Hattori N et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 1998;392:605–608.

[10] Liu Y, Huang W, Wen J et al. Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles. Neural Regen Res 2025;20:1124–1134.

[11] Narendra D, Tanaka A, Suen DF et al. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 2008;183:795–803.

[12] Song P, Peng W, Sauve V et al. Parkinson’s disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons. Neuron 2023;111:3775–3788 e7.

[13] Wang H, Song P, Du L et al. Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease. J Biol Chem 2011;286:11649–11658.

[14] Yang W, Liu Y, Tu Z et al. CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys. Cell Res 2019;29:334–336.

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