CRL3 E3 ligase regulates glutamine and cystine metabolisms

Qiyin Zhou; Zhijian Li; Yi Sun

doi:10.1093/procel/pwae051

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Protein Cell ›› 2024, Vol. 15 ›› Issue (12) : 867-871. DOI: 10.1093/procel/pwae051

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CRL3 E3 ligase regulates glutamine and cystine metabolisms

Qiyin Zhou¹^,²^,³^,⁴ ,
Zhijian Li²^,³ ,
Yi Sun¹^,²^,³^,⁴^,⁵

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Qiyin Zhou, Zhijian Li, Yi Sun. CRL3 E3 ligase regulates glutamine and cystine metabolisms. Protein Cell, 2024, 15(12): 867‒871 https://doi.org/10.1093/procel/pwae051

References

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[1]	An J, Ren S, Murphy SJ et al. Truncated ERG oncoproteins from TMPRSS2-ERG fusions are resistant to SPOP-mediated proteasome degradation. Mol Cell 2015;59:904–916. CrossRef Google scholar

[2]	Bonifacio VDB, Pereira SA, Serpa J et al. Cysteine metabolic circuitries: druggable targets in cancer. Br J Cancer 2021;124:862–879. CrossRef Google scholar

[3]	Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 2021;12:599–620. CrossRef Google scholar

[4]	Lobel GP, Jiang Y, Simon MC. Tumor microenvironmental nutrients, cellular responses, and cancer. Cell Chem Biol 2023;30:1015–1032. CrossRef Google scholar

[5]	Muir A, Danai LV, Gui DY et al. Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition. Elife 2017;6:e27713. CrossRef Google scholar

[6]	Pavlova NN, Thompson CB. The emerging hallmarks of cancer metabolism. Cell Metab 2016;23:27–47. CrossRef Google scholar

[7]	Stockwell BR. Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications. Cell 2022;185:2401–2421. CrossRef Google scholar

[8]	Timmerman LA, Holton T, Yuneva M et al. Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell 2013;24:450–465. CrossRef Google scholar

[9]	Vogl AM, Phu L, Becerra R et al. Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics. Nat Struct Mol Biol 2020;27:210–220. CrossRef Google scholar

[10]	Yang L, Venneti S, Nagrath D. Glutaminolysis: a hall-mark of cancer metabolism. Annu Rev Biomed Eng 2017;19:163–194. CrossRef Google scholar

[11]	Zhang C, Yu JJ, Yang C et al. Crosstalk between ferroptosis and stress-Implications in cancer therapeutic responses. Cancer Innov 2022;1:92–113. CrossRef Google scholar

[12]	Zhang S, Yu Q, Li Z et al. Protein neddylation and its role in health and diseases. Signal Transduct Target Ther 2024;9:85. CrossRef Google scholar

[13]	Zhao Y, Sun Y. Cullin-RING Ligases as attractive anti-cancer targets. Curr Pharm Des 2013;19:3215–3225. CrossRef Google scholar

[14]	Zhou L, Zhang W, Sun Y et al. Protein neddylation and its alterations in human cancers for targeted therapy. Cell Signal 2018;44:92–102. CrossRef Google scholar

[15]	Zhou Q, Li H, Li Y et al. Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells. JCI Insight 2019;4:e121582. CrossRef Google scholar

[16]	Zhou Q, Lin W, Wang C et al. Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3(SPOP) e3 ligase in cancer cells. Nat Commun 2022;13:3034. CrossRef Google scholar

[17]	Zhou Q, Yu H, Chen Y et al. The CRL3(KCTD10) ubiquitin ligase-USP18 axis coordinately regulates cystine uptake and ferroptosis by modulating SLC7A11. Proc Natl Acad Sci U S A 2024;121:e2320655121. CrossRef Google scholar

[18]	Zhuang M, Calabrese MF, Liu J et al. Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases. Mol Cell 2009;36:39–50. CrossRef Google scholar