Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy

References

[1] Cao C, Rioult-Pedotti MS, Migani P et al. Impairment of TrkB-PSD-95 signaling in Angelman syndrome. PLoS Biol 2013;11:e1001478.

[2] Castillo B, Jr., del Cerro M et al. Retinal ganglion cell survival is promoted by genetically modified astrocytes designed to secrete brain-derived neurotrophic factor (BDNF). Brain Res 1994;647:30–36.

[3] Fudalej E, Justyniarska M, Kasarello K et al. Neuroprotective factors of the retina and their role in promoting survival of retinal ganglion cells: a review. Ophthalmic Res 2021;64:345–355.

[4] Ji Y, Pang PT, Feng L et al. Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nat Neurosci 2005;8:164–172.

[5] Kern TS, Barber AJ. Retinal ganglion cells in diabetes. J Physiol 2008;586:4401–4408.

[6] Kimura A, Namekata K, Guo X et al. Neuroprotection, growth factors and BDNF-TrkB signalling in retinal degeneration. Int J Mol Sci 2016;17:1584.

[7] Lau KA, Yang X, Rioult-Pedotti MS et al. A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome. Prog Neurobiol 2023;230:102513.

[8] Marshall J, Zhou XZ, Chen G et al. Antidepression action of BDNF requires and is mimicked by Galphai1/3 expression in the hippocampus. Proc Natl Acad Sci U S A 2018;115:E3549–E3558.

[9] Naik MT, Naik N, Hu T et al. Structure-based design of peptidomimetic inhibitors of PSD-95 with improved affinity for the PDZ3 domain. FEBS Lett 2024;598:233–241.

[10] Sabanayagam C, Banu R, Chee ML et al. Incidence and progression of diabetic retinopathy: a systematic review. Lancet Diabetes Endocrinol 2019;7:140–149.

[11] Seki M, Tanaka T, Nawa H et al. Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived neurotrophic factor for dopaminergic amacrine cells. Diabetes 2004;53:2412–2419.

[12] Taslipinar Uzel AG, N UG, Toklu Y et al. Relationship between stages of diabetic retinopathy and levels of brain-derived neurotrophic factor in aqueous humor and serum. Retina 2020;40:121–125.

[13] Yanpallewar SU, Barrick CA, Buckley H et al. Deletion of the BDNF truncated receptor TrkB.T1 delays disease onset in a mouse model of amyotrophic lateral sclerosis. PLoS One 2012;7:e39946.

RIGHTS & PERMISSIONS

The Author(s) 2024. Published by Oxford University Press on behalf of Higher Education Press.