Tanjun Tong: a pioneer of cellular senescence and aging mechanism research in China

References

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[2] Cai J, Tong T. Effect of EGF on the activity of P34^cdc2 kinase in mouse embryo fibroblast cell line. Acta Biochim Biophys Sin 1994a;26:423–426. (蔡家新, 童坦君. (1994a). 表皮生长因子对P34^cdc2激酶活性的影响. 生物化学与生物物理学报, 26(4), 423-426.)

[3] Cai J, Tong T. Effect of epidermal growth factor on cell cycle in mouse embryo fibroblast cell line. Chin Biochem J 1994b;10:218–222. (蔡家新, 童坦君. (1994b). 表皮生长因子对鼠胚成纤维细胞细胞周期的调节作用. 生物化学杂志, 10(2), 218-222.)

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[6] Chen L, Tong T, Qian M. The effects of three Chinese medical herbs on the Na⁺-K⁺ ATPase activity of erythrocyte membranes in mice during aging. Physiol Sci 1986;6:385–385. (陈林, 童坦君, 钱曼琴. (1986). 桑椹、鹿茸、黄芪对增龄过程小鼠红细胞膜Na⁺-K⁺ ATP酶活性的影响. 生理科学, 6(5), 385–386.)

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[8] Chen P, Tong T, Zhang Z. The role of p16 methylation in the aging of human fetal lung diploid fibroblasts. Chin J Geriatr 2001;20:44–44. (陈培利, 童坦君, 张宗玉. (2001). p16基因甲基化在人二倍体成纤维细胞衰老中的作用. 中华老年医学杂志, 20(1), 44–46.)

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[10] Cheng Q, Yuan F, Lu F et al. CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression. Oncotarget 2015;6:4733.

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[12] Duan J, Zhang Z, Tong T. Senescence delay of human diploid fibroblast induced by anti-sense p16^INK4a expression. J Biol Chem 2001;276:48325–48325.

[13] Duan J, Chen Z, Liu P et al. Wild-type p16^INK4a suppresses cell growth, telomerase activity and DNA repair in human breast cancer MCF-7 cells. Int J Oncol 2004;24: 1597–1605.

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[15] Fu J, Huang D, Yuan F et al. TRAF-interacting protein with forkhead-associated domain (TIFA) transduces DNA damage–induced activation of NF-κB. J Biol Chem 2018;293:7268–7268.

[16] Gan Q, Huang J, Zhou R et al. PPARγ accelerates cellular senescence by inducing p16^INK4α expression in human diploid fibroblasts. J Cell Sci 2008;121:2235–2235.

[17] Gong Q, Tong T. Isolation and identification of high molecular weight DNA-binding proteins from serum of mice with Ehrlich ascites carcinoma. J Beijing Med Univ 1991a;23:5. (龚秋明, 童坦君. (1991a). 艾氏腹水癌患鼠血清高分子量DNA结合蛋白的分离与鉴定. 北京医科大学学报, 23(1), 5.)

[18] Gong Q, Tong T. Purification and characterization of a tumor-associated high molecular weight serum DNA binding protein. J Beijing Med Univ 1991b;23:59–66. (龚秋明, 童坦君. (1991b). Purification and characterization of a tumor-associated high molecular weight serum DNA binding protein. 北京医科大学学报, 23(1), 59–66.)

[19] Gong Q, Tong T, Yang S. DNA-binding proteins in serum of non-cancerous mice. Physiol Sci 1983;3:29. (龚秋明, 童坦君, 杨世欣. (1983). 非癌疾患小鼠血清的脱氧核糖核酸结合蛋白. 生理科学, 3(4), 29.)

[20] Gong Q, Tong T, Yang S. Study on DNA-binding proteins in body fluids Ⅲ. DNA-binding proteins in serum of non-cancerous mice. J Beijing Med College 1984;16:26–26. (龚秋明, 童坦君, 杨世欣. (1984). 体液脱氧核糖核酸结合蛋白的研究Ⅲ. 非癌疾患小鼠血清脱氧核糖核酸结合蛋白. 北京医学院学报, 16(1), 26–29.)

[21] Guo S, Zhang Z, Tong T. Cloning and characterization of cellular senescence-associated genes in human fibroblasts by suppression subtractive hybridization. Exp Cell Res 2004;298:465–465.

[22] Guo GE, Ma LW, Jiang B et al. Hydrogen peroxide induces p16INK4a through an AUF1-dependent manner. J Cell Biochem 2010;109:1000–1000.

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[26] Han L, Zhao G, Wang H et al. Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells. Clin Exp Pharmacol Physiol 2014;41:165–165.

[27] Huang S, Tong T. The role of translational regulation in gene expression. Chem Life 1987;7:16–16. (黄石, 童坦君. (1987). 翻译水平的调控在基因表达中的作用. 生命的化学, 7(3), 16–17.)

[28] Huang P, Shi X, Tong T. Effect of epidermal growth factor on the activity of chromatin-associated protein kinases of normal and transformed C3H/10T1/2CI8 Cells. Chin Biochem J 1989;5:503–503. (黄平, 石星源, 童坦君. (1989). 表皮生长因子对正常细胞与转化细胞染色质蛋白激酶活性的影响. 生物化学杂志, 5(6), 503–508.)

[29] Huang Z, Wang X, Peng X et al. Deletion of Rb gene in human stomach cancer. Chin Biochem J 1993;9:448–448. (黃昭暘, 王新娟, 彭晓冬, 曾菲菲, 王立新, 童坦君, 许中伟, 林三仁. (1993). Rb基因在人胃癌中异常的初步观察. 生物化学杂志, 9(4), 448–453.)

[30] Huang Y, Yang L, Zhang Z et al. Exogenous p21^WAF1 transfection affects apoptosis in human fibroblasts. Acta Biochim Biophys Sin 2000a;32:35–38. (黄英, 杨龙, 张宗玉, 童坦君. (2000). 外源p21^WAF1转染对人成纤维细胞凋亡的影响. 生物化学与生物物理学报, 32(1), 35–38.)

[31] Huang Y, Zhang Z, Tong T. The expression of p21^WAF1 during sodium butyrate-induced apoptosis in human fibroblast. Prog Biochem Biophys 2000b;27:182–185. (黄英, 张宗玉, 童坦君. (2000). p21^WAF1在丁酸钠诱导的人成纤维细胞凋亡中的表现. 生物化学与生物物理进展, 27(2), 182–185.)

[32] Huang Y, Corbley MJ, Tang Z et al. Down-regulation of p21^WAF1 promotes apoptosis in senescent human fibroblasts: involvement of retinoblastoma protein phosphorylation and delay of cellular aging. J Cell Physiol 2004;201:483–483.

[33] Huang J, Gan Q, Han L et al. SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. PLoS One 2008;3:e1710.

[34] Huang Y, Wu J, Li R et al. B-MYB delays cell aging by repressing p16^INK4α transcription. Cell Mol Life Sci 2011;68:893–893.

[35] Jiang Z, Hao F, Zhu F et al. RSL1D1 modulates cell senescence and proliferation via regulation of PPARγ mRNA stability. Life Sci 2022;307:120848.

[36] Jin M, Tong T, Li B. Southern molecular hybridization to detect c-erbB2/neu gene abnormalities in gastric cancer tissue. J Beijing Med Univ 1993;25:460. (金曼林, 童坦君, 李滨. (1993). Southern分子杂交术检测胃癌组织c-erbB2/neu基因异常. 北京医科大学学报, 25(6), 460.)

[37] Li B, Tong T. Single-strand configuration polymorphism analysis to detect erbB-2 gene abnormalities in gastric cancer. Chin Med J 1994a;74:440–441. (李滨, 童坦君. (1994). 单链构型多态分析检测胃癌erbB-2基因异常. 中华医学杂志, 74(7), 440–441.)

[38] Li J, Tong T. The effect of peptide growth factors on the activity of DNA topoisomerases in isolated nuclei of mouse fibroblast. Chin Biochem J 1994b;10:477–480. (李建义, 童坦君. (1994). 肽类生长因子对游离细胞核中拓扑异构酶活性的影响. 生物化学杂志, 10(4), 477–480.)

[39] Li J, Tong T. Nerve growth factor can increase the transcription activity of purified nuclei. J Beijing Med Univ 1995a;27:246–248. (李建义, 童坦君. (1995a). 神经生长因子对成纤维细胞游离细胞核的促转录作用. 北京医科大学学报, 27(4), 246–248.)

[40] Li J, Tong T. Study on the nuclear effects of epidermal growth factor. Chin Biochem J 1995b;11:529–534. (李建义, 童坦君. (1995b). 表皮生长因子对游离细胞核特异基因体外转录的影响. 生物化学杂志, 11(5), 529–534.)

[41] Li J, Zhang Z, Tong T. Expression of anti-oncogenes in old 2BS cells after epidermal growth factor stimulation. Chin J Geriatr 1994a;13:195–197. (李江红, 张宗玉, 童坦君. (1994a). 表皮生长因子对衰老2BS细胞抗癌基因表达的影响. 中华老年医学杂志, 13(4), 195–197.)

[42] Li J, Zhang Z, Tong T. Induction of anti-oncogenes by peptide growth factors. Chin Biochem J 1994b;10:626–629. (李江红, 张宗玉, 童坦君. (1994b). 肽类生长因子对抗癌基因的诱导作用. 生物化学杂志, 10(5), 626–629.)

[43] Li B, Peng Y, Tong T. Primary analysis of the structure of neu oncogene in normal and transformed C3H mouse embryo fibroblasts. Chin Biochem J 1995a;11:525–528. (李滨, 彭勇, 童坦君. (1995). 正常的和转化的C3H小鼠胚胎成纤维细胞neu基因结构的初步研究. 生物化学杂志, 11(5), 525–528.)

[44] Li J, Zhang Z, Tong T. The proliferative response and anti-oncogene expression in old 2BS cells after growth factor stimulation. Mech Ageing Dev 1995b;80:25–34.

[45] Li S, Zhang Z, Tong T. Phosphatidylinositol 3-kinase inhibitor, LY294002, induced senescence-like changes in human diploid fibroblasts. Chin Med J (Engl) 2003;116:901–901.

[46] Li N, Li Q, Cao X et al. The tumor suppressor p33^ING1b upregulates p16^INK4a expression and induces cellular senescence. FEBS Lett 2011a;585:3106–3112.

[47] Li R, Ma L, Huang Y et al. Characterization of a novel positive transcription regulatory element that differentially regulates the alpha-2-macroglobulin gene in replicative senescence. Biogerontology 2011b;12:517–525.

[48] Li N, Zhao G, Chen T et al. Nucleolar protein CSIG is required for p33^ING1 function in UV-induced apoptosis. Cell Death Dis 2012;3:e283–e283.

[49] Li Q, Zhang Y, Fu J et al. FOXA1 mediates p16^INK4a activation during cellular senescence. EMBO J 2013;32:858–858.

[50] Liu Y, Tong T. Growth inhibitory effect of novel epidermal pentapeptide on malignant transformed cells. J Beijing Med Univ 1993;25:7. (刘英, 童坦君. (1993). 新型生长抑肽对恶性转化细胞的生长抑制作用. 北京医科大学学报, 25(1), 7.)

[51] Liu Y, Tong T. Effect of a novel negative growth peptide on DNA synthesis and some oncogenes expression in fibroblast. Chin Biochem J 1995;11:35–35. (刘英, 童坦君. (1995). 新型生长抑肽对成纤维细胞的DNA合成及某些癌基因表达的影响. 生物化学杂志, 11(1), 35–39.)

[52] Liu Y, Tong T. The growth-inhibiting epidermal pentapeptide, pyroGlu-glu-asp-ser-GlyOH, inhibits growth and alters gene expression in non-transformed NC3H10 and transformed TC3H10 fibroblasts. Oncol Rep 1999;6:445–445.

[53] Liu Y, Gong Q, Tong T. Isolation of a high molecular weight DNA-binding protein from the serum of mice with H22 ascites liver cancer. J Beijing Med Univ 1989;21:372. (刘宇红, 龚秋明, 童坦君. (1989). H22腹水型肝癌患鼠血清中一种高分子量DNA结合蛋白的分离. 北京医科大学学报, 21(5), 372.)

[54] Liu Y, Gong Q, Tong T. Isolation and characterization of a high molecular weight DNA binding protein from ascites of mice with Ehrlich ascites carcinoma. Chin Biochem J 1990;6:264–264. (刘宇红, 龚秋明, 童坦君. (1990). 艾氏腹水癌患鼠腹水中一种高分子量DNA结合蛋白的分离. 生物化学杂志, 6(3), 264–267.)

[55] Liu P, Tong T, Zhang Z. Cell cycle negative regulator p16 induces senescence-like alterations in human fibroblasts (2BS). Chin J Geriatr 2001;20:128–128. (刘平湖, 童坦君, 张宗玉. (2001). 细胞周期抑制因子p16可诱导人成纤维细胞发生衰老样变化. 中华老年医学杂志, 20(2), 128-131.)

[56] Ma H, Zhang Z, Tong T. The effects of epidermal growth factor on gene expression in human fibroblasts. In Vitro Cell Dev Biol Anim 2002;38:481–481.

[57] Ma H, Li R, Zhang Z et al. mRNA level of alpha-2-macroglobulin as an aging biomarker of human fibroblasts in culture. Exp Gerontol 2004;39:415–415.

[58] Ma L, Chang N, Guo S et al. CSIG inhibits PTEN translation in replicative senescence. Mol Cell Biol 2008;28:6290–6290.

[59] Ma L, Zhao W, Zhu F et al. Global characteristics of CSIG-associated gene expression changes in human HEK293 cells and the implications for CSIG regulating cell proliferation and senescence. Front Endocrinol 2015;6:69.

[60] Ma L, Zhao W, Zheng Q et al. Ribosomal L1 domain and lysine-rich region are essential for CSIG/RSL1D1 to regulate proliferation and senescence. Biochem Biophys Res Commun 2016;469:593–593.

[61] Mao Z, Zhang Z, Tong T. Induction of c-fos/c-myc expression by epidermal growth factor decreases with alteration of their gene binding proteins in senescent fibroblasts. Chin Med J (Engl) 1997;110:755–755.

[62] Mao Z, Shan S, Zhu Y et al. Transcriptional regulation of A33 antigen expression by gut-enriched Krüppel-like factor. Oncogene 2003;22:4434–4434.

[63] Niu J, Chen T, Han L et al. Transcriptional activation of the senescence regulator Lsh by E2F1. Mech Ageing Dev 2011;132:180–180.

[64] Peng Y, Tong T. Study on endocytosis and nuclear accumulation o epidermal growth factor (EGF) in normal C3H mouse fibroblast cells C3H10T1/2C18 and 3H-TdR transformed counterpart cells. Acta Biologiae Experimentalis Sinica 1993;26:179–179. (彭勇, 童坦君. (1993). 成纤维细胞表皮生长因子的胞吞和向细胞核转移研究. 实验生物学报, 26(3), 179–186.)

[65] Peng X, Wang X, Tong T et al. A case report of Rb gene deletion and c-myc gene amplification in human gastric cancer. J Beijing Med Univ 1992;24:99. (彭晓冬, 王新娟, 童坦君, 石东萍, 林三仁. (1992). 人胃癌Rb基因缺失和c-myc基因扩增1例报告. 北京医科大学学报, 24(2), 99.)

[66] Peng Y, Tong T, Zhang C. Study on epidermal growth factor receptor (EGFR) of mouse embryo fibroblast C3H10T1/2CL8 after malignant transformation. Chin Biochem J 1993a;9:51–55. (彭勇, 童坦君, 张昌颖. (1993a). 恶性转化的成纤维细胞表皮生长因子受体的研究. 生物化学杂志, 9(9), 51–55.)

[67] Peng Y, Tong T, Zhang C. Study on the effect of epidermal growth factor on DNA methylation. Sci China (Ser B) 1993b;23:291–296. (彭勇, 童坦君, 张昌颖. (1993b). 表皮生长因子对DNA甲基化影响的研究. 中国科学(B辑化学/生命科学地学), 23(3), 291–296.)

[68] Peng Y, Tong T, Zhang C. Study on the effects of epidermal growth factor on binding proteins of EGFR gene and proto-oncogenes c-fos and c-myc. Chin Biochem J 1993c;9:400–405. (彭勇, 童坦君, 张昌颖. (1993c). EGF对EGFR基因和c-fos、c-myc原癌基因DNA结合蛋白质的影响. 生物化学杂志, 9(4), 400–405.)

[69] Peng Y, Tong T, Zhang C. Direct effects of epidermal growth factor on transcription activity of isolated nuclei. Chin Biochem J 1994;10:466–466. (彭勇, 童坦君, 张昌颖. (1994). 表皮生长因子对细胞核转录活性的直接作用. 生物化学杂志, 10(4), 466–470.)

[70] Tang Z, Zhang Z, Tong T. Study on the sensitivity of epidermal growth factor and the expression of its receptor-related genes during the aging process of human fibroblast (2BS) cells. J Beijing Med Univ 1991;23:408. (唐左勤, 张宗玉, 童坦君. (1991). 人成纤维(2BS)细胞衰老过程中表皮生长因子感受性及其受体相关基因表达的研究. 北京医科大学学报, 23(5), 408.)

[71] Tang Z, Zhang Z, Zheng Y et al. Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in HER-2 expression. Mech Ageing Dev 1994;73:57–57.

[72] Tian F, Li J, Liu X et al. Age-dependent accumulation of mitochondrial DNA deletions in the aortic root of atherosclerosis-prone apolipoprotein E-knockout mice. Arch Gerontol Geriatr 2016;63:72–72.

[73] Tong T. Protein biosynthesis. Sci Bull 1975;20:162–162. (童坦君. (1975). 蛋白质的生物合成. 科学通报, 20(04), 162–172.)

[74] Tong T. Chalone and Cancer. Foreign Med Ref (Oncology Volume) 1976:147–155. (童坦君. (1976). 抑素与癌. 国外医学参考资料(肿瘤学分册)(4), 147–155.)

[75] Tong T. Effect of human β interferon on epidermal growth factor promoting 3H-TdR incorporation. Physiol Sci 1983a;3:40. (童坦君. (1983a). 人β干扰素对表皮生长因子促3H-脱氧胸苷参入作用的影响. 生理科学, 3(3), 40.)

[76] Tong T. Growth inhibitory effect of human α interferon on sarcoma cells. Physiol Sci 1983b;3:40. (童坦君. (1983b). 人α干扰素对肉瘤细胞的生长抑制作用. 生理科学, 3(3), 40.)

[77] Tong T. Inhibitory effect of human α interferon on fibrinolytic activity of human sarcoma cells. Physiol Sci 1983c;3:52–53.

[78] Tong T. Insensitivity of human sarcoma cells to epidermal growth factor. Physiol Sci 1983d;3:41. (童坦君. (1983d). 人肉瘤细胞对表皮生长因子的不敏感性. 生理科学, 3(3), 41.)

[79] Tong T. Research progress on protein synthesis and regulation. Biol Bull 1987;22:19–19. (童坦君. (1987). 蛋白质的合成及其调节的研究进展. 生物学通报, 22(2), 19–22.)

[80] Tong T. Biochemistry. Peking University Medical Press, 2003. (童坦君. (2003). 生物化学. 北京大学医学出版社.)

[81] Tong T, Chen M. Tumor suppressor activity of body fluids. Scientia Sin 1978;8:694–694. (童坦君, 陈明. (1978). 体液的抑癌活性. 中国科学, 8(6), 694–702.)

[82] Tong T, Chen M. Cancer-suppressive activity of biological fluids. Scientia Sin 1979;22:835–835.

[83] Tong T, Liu S. Study on ammonia detoxification in rats with liver cancer. J Beijing Med College 1965:247–250. (童坦君, 刘思职. (1965). 肝癌大鼠的氨解毒研究. 北京医学院学报(4), 247–250.)

[84] Tong T, Liu D. Isolation and identification of glycopeptides in edible bird’s nest. Physiol Sci 1984;4:19–19. (童坦君, 刘德勇. (1984). 燕窝糖肽的分离与鉴定. 生理科学, 4(1), 19–20.)

[85] Tong T, Liu D. Isolation and identification of glycopeptides in edible bird’s nest. Sci Bull 1985;30:949–949. (童坦君, 刘德勇. (1985). 燕窝糖肽的分离与鉴定. 科学通报, 30(12), 949–952.)

[86] Tong T, Zhang C. Regulation of protein synthesis in mammals. Prog Biochem Biophys 1978;5:40–40. (童坦君, 张昌颖. (1978). 哺乳动物体内蛋白质合成的调节. 生物化学与生物物理进展, 5(5), 40–43.)

[87] Tong T, Zhang N. Structure and function of mammalian messenger RNA. Prog Physiol Sci 1979;10:68–68. (童坦君, 张迺蘅. (1979). 哺乳动物信使核糖核酸的结构与功能. 生理科学进展, 10(1), 68–75.)

[88] Tong T, Zhang Z. Medical Gerontology: Aging and Longevity. People’s Medical Publishing House Co, 1995. (童坦君, 张宗玉. (1995). 医学老年学—衰老与长寿. 人民卫生出版社.)

[89] Tong T, Sun Q, Yang S et al. Study on DNA-binding proteins in body fluids II. DNA-binding proteins in serum of cancerous mice. Physiol Sci 1983a;3:30. (童坦君, 孙诠, 杨世欣, 吴平, 张昌颖. (1983). 体液脱氧核糖核酸结合蛋白的研究 II. 患癌小鼠血清脱氧核糖核酸结合蛋白. 生理科学, 3(4), 30.)

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[94] Tong T, Chen L, Xu M. Regular changes of Na⁺-K⁺ ATPase activity in erythrocyte membrane during the aging process of mice. Physiol Sci 1986;6:384–384. (童坦君, 陈林, 许敏. (1986). 小鼠增龄过程红细胞膜Na⁺-K⁺ ATP酶活性的规律变化. 生理科学, 6(5), 384–385.)

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[97] Wang L, Tong T. Negative regulatory effect of nerve growth factor on fibroblast growth. Prog Biochem Biophys 1992;19:471–471. (王丽辉, 童坦君. (1992). 神经生长因子对成纤维细胞生长的负调节作用. 生物化学与生物物理进展, 19(6), 471–473.)

[98] Wang L, Tong T, Zheng Y. The effect of EGF on the activity of DNA topoisomerase in transformed mouse fibroblast. Chin Biochem J 1992;8:706–706. (王丽辉, 童坦君, 郑玉荣. (1992). 表皮生长因子对转化的小鼠成纤维细胞DNA拓扑异构酶活性的影响. 生物化学杂志, 8(6), 706–710.)

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[108] Xu L, Tong T. Regulatory effects of epidermal growth factor on cell growth and proliferation. Prog Physiol Sci 1988;19:36–36. (许立成, 童坦君. (1988). 表皮生长因子对细胞生长和增殖的调节作用. 生理科学进展, 19(1), 36–38.)

[109] Xu L, Tong T. A rapid and simple method for separation of phosphotyrosine from phosphoserine and phosphothreonine. J Beijing Med Univ 1989;21:180–180. (许立成, 童坦君. (1989). 酪氨酸蛋白激酶研究中磷酰酪氨酸的快速分离与鉴定. 北京医科大学学报, 21(3), 180–182.)

[110] Xu L, Tong T, Zhang C et al. Study on tyrosine-specific phosphorylation of 3H-TdR-transformed C3H10T1/2CL8. Chin Biochem J 1987;3:567–567. (许立成, 童坦君, 张昌颖, 朴长青. (1987). 3H-TdR转化细胞蛋白质酪氨酸残基的特异磷酸化. 生物化学杂志, 3(6), 567–569.)

[111] Xu L, Tong T, Zhang C. Study on the sensitivity of transformed cells and ascites cancer cells to growth regulatory factors. Chin Biochem J 1988;4:103–103. (许立成, 童坦君, 张昌颖. (1988). 转化细胞及腹水癌细胞对生长调节因子敏感性的研究. 生物化学杂志, 4(2), 103–108.)

[112] Xue L, Wu J, Zheng W et al. Sp1 is involved in the transcriptional activation of p16^INK4 by p21^Waf1 in HeLa cells. FEBS Lett 2004;564:199–199.

[113] Yang S, Tong T, Wang H et al. DNA-binding protein in erythrocytes of malaria mice. Sci Bull 1986;31:1600. (杨世欣, 童坦君, 王华, 张昌颖, 叶鑫生, 程道新. (1986). 患疟疾小鼠红细胞内脱氧核糖核酸结合蛋白. 科学通报, 31(20), 1600.)

[114] Yang S, Tong T, Wang H et al. DNA-binding protein in the erythrocyte of mice infected with Plasmodium berghei and Plasmodium yoelii. Sci Bull 1987;32:1654–1654. (杨世欣, 童坦君, 王华, 张昌颖, 叶鑫生, 程道新. (1987). DNA-binding protein in the erythrocyte of mice infected with Plasmodium berghei and Plasmodium yoelii. ??科学通报英文版???, 32(23), 1654–1655.)

[115] Yu L, Tong T, Zhang C. A serum DNA binding protein with chymotrypsin inhibition activity—purification and characterization. Chin Biochem J 1987;3:441–441. (於利敏, 童坦君, 张昌颖. (1987). 一种具有抑制糜蛋白酶活性的血清DNA结合蛋白质的纯化和理化特性. 生物化学杂志, 3(5), 441–448.)

[116] Yu L, Tong T, Zhang C. Detection of serum 64DP in tumor patients by ELISA. Chin Biochem J 1988;4:263–263. (於利敏, 童坦君, 张昌颖. (1988). ELISA检测肿瘤患者血清64DP. 生物化学杂志, 4(3), 263–268.)

[117] Yu L, Tong T, Jiang Z et al. The binding of 64DP with human chromatin and the detection of 64DP in nucleus. Chin Biochem J 1991;7:482–482. (于利敏, 童坦君, 姜众, 张昌颖, 谭承顷. (1991). 64DP与人染色质的结合反应及细胞核内64DP的检测. 生物化学杂志, 7(4), 482–486.)

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[122] Zhang X, Tong T. The inhibitory effect of antisense adenovirus vector of telomerase on telomerase activity in breast cancer cells MCF-7. Chin J Pathol 2000;29:188–188. (张晓伟, 童坦君. (2000). 端粒酶反义腺病毒载体对乳腺癌细胞MCF-7端粒酶的抑制作用. 中华病理学杂志, 29(3), 188–191.)

[123] Zhang X, Tong T. The inhibition of antisense telomerase cDNA to malignant phenotype of breast cancer cells. Chin J Biochem Mol Biol 2001;17:395–395. (张晓伟, 童坦君. (2001). 端粒酶反义cDNA对乳腺癌细胞恶性表型的影响. 中国生物化学与分子生物学报, 17(3), 395–400.)

[124] Zhang Z, Tong T. Healthily Live One Hundred Years with Enjoyment. Beijing: Peking University Medical Press, 2006. (张宗玉, 童坦君. (2006). 健健康康活百岁 有滋有味过百年. 北京大学医学出版社, 北京.)

[125] Zhang Y, Tong T. FOXA1 antagonizes EZH2-mediated CDKN2A repression in carcinogenesis. Biochem Biophys Res Commun 2014;453:172–172.

[126] Zhang Z, Fan X, Tong T. Change of telomere length of human embryo lung diploid fibroblasts (2BS) at different population doublings. Chin Biochem J 1997a;13:43–45. (张宗玉, 范新青, 童坦君. (1997a). 人胚肺二倍体成纤维细胞端区长度的代龄变化. 生物化学杂志, 13(1), 43–45.)

[127] Zhang Z, Fan X, Tong T. Telomere length shortened in peripheral blood leukocytes during Chinese aging. Chin Biochem J 1997b;13:605–607. (张宗玉, 范新青, 童坦君. (1997b). 中国人外周血白细胞端区DNA长度随增龄缩短. 生物化学杂志, 13(5), 605–607.)

[128] Zhang X, Liao H, Tong T. Telomere shortening of MCF-7 cells caused by antisense telomerase cDNA. Acta Biochim Biophys Sin 1999;31:527–527. (张晓伟, 廖海妮, 童坦君. (1999). 端粒酶RNA的反义cDNA对乳腺癌细胞端区长度的影响. 生物化学与生物物理学报, 31(5), 527–530.)

[129] Zhang X, Chen Y, Tong T. Effect of antisense telomerase cDNA on the DNA repair ability of breast cancer cells. Chin J Biochem Mol Biol 2001a;17:401–405. (张晓伟, 陈彦灵, 童坦君. (2001a). 端粒酶反义cDNA对乳腺癌细胞损伤修复能力的影响. 中国生物化学与分子生物学报, 17(3), 401–405.)

[130] Zhang X, Chen Y, Tong T. Effect of antisense telomerase RNA on apoptosis of breast cancer cells. Chin J Biochem Mol Biol 2001b;17:447–452. (张晓伟, 陈彦灵, 童坦君. (2001b). 端粒酶RNA的反义cDNA对乳腺癌细胞凋亡的影响. 中国生物化学与分子生物学报, 17(4), 447–452.)

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[132] Zhao L, Tong T, Zhang Z. Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts. FASEB J 2005;19:521–521.

[133] Zhao W, Ma L, Tong T. Research progress on cell senescence suppressor gene CSIG. Prog Physiol Sci 2012;43:291–291. (赵文婷, 马利伟, 童坦君. (2012). 细胞衰老抑制基因CSIG研究进展. 生理科学进展, 43(4), 291–293.)

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[137] Zheng Y, Tong T. Expression of epidermal growth factor receptor gene and its related oncogenes in radiationtransformed cells. J Beijing Med Univ 1991;23:337. (郑元盛, 童坦君. (1991). 表皮生长因子受体基因及其相关癌基因在射线转化细胞中的表达. 北京医科大学学报, 23(4), 337.)

[138] Zheng Y, Tong T. The effect of epidermal growth factor on the expression of erb B2/neu oncogene in mouse embryo fibroblast cells. Acta Biologiae Experimentalis Sinica 1992;25:413–413. (郑元盛, 童坦君. (1992). 表皮生长因子对neu基因表达的诱导作用(简报). 实验生物学报, 25(4), 413–416.)

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[142] Zhou A, Tong T, Chen M. Specificity of humoral tumor suppressor activity. Scientia Sin 1980;10:1011–1011. (周爱如, 童坦君, 陈明. (1980). 体液抑癌活性的专一性. 中国科学, 10(10), 1011–1016.)

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