Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft

Huaxiang Zhao; Wenjie Zhong; Wenbin Huang; Guozhu Ning; Jieni Zhang; Mengqi Zhang; Peiqi Meng; Yunfan Zhang; Qian Zhang; Hongping Zhu; Gulibaha Maimaitili; Yi Ding; Weiran Li; Wei Liang; Zhibo Zhou; Qiang Wang; Feng Chen; Jiuxiang Lin

doi:10.1093/procel/pwae021

Protein Cell ›› 2024, Vol. 15 ›› Issue (10) : 783 -789. DOI: 10.1093/procel/pwae021

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Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft

Huaxiang Zhao ¹^,²
, Wenjie Zhong ¹^,³
, Wenbin Huang ¹^,⁴
, Guozhu Ning ⁵
, Jieni Zhang ¹^,⁶
, Mengqi Zhang ¹
, Peiqi Meng ¹
, Yunfan Zhang ¹
, Qian Zhang ⁶^,⁷
, Hongping Zhu ⁶^,⁸
, Gulibaha Maimaitili ⁹
, Yi Ding ¹⁰
, Weiran Li ¹^,⁶
, Wei Liang ¹^,⁶^,^†
, Zhibo Zhou ⁶^,⁸^,^†
, Qiang Wang ¹¹^,^†
, Feng Chen ⁶^,⁷^,^†
, Jiuxiang Lin ¹^,⁶^,^†

Author information +

¹. Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China

². Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an 710049, China

³. College of Stomatology, Chongqing Medical University; Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing 400016, China

⁴. Department of Orthodontics, Stomatological Center, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen 518036, China

⁵. Affiliated Hospital of Guangdong Medical University & Zhanjiang Key Laboratory of Zebrafish Model for Development and Disease, Guangdong Medical University, Zhanjiang 524023, China

⁶. National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory for Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, NMPA Key Laboratory for Dental Materials, Beijing 100191, China

⁷. Central Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China

⁸. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100191, China

⁹. The Second Affiliated Hospital of Xinjiang Medical University and Xinjiang Key Laboratory of Neurological Disorder Research, Urumqi 830028, China

¹⁰. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an 710049, China

¹¹. Innovation Centre of Ministry of Education for Development and Diseases, Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou 511442, China

bmuliang@bjmu.edu.cn

zzbooo@126.com

qiangwang@scut.edu.cn

chenfeng2011@hsc.pku.edu.cn

jxlin@pku.edu.cn

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Huaxiang Zhao, Wenjie Zhong, Wenbin Huang, Guozhu Ning, Jieni Zhang, Mengqi Zhang, Peiqi Meng, Yunfan Zhang, Qian Zhang, Hongping Zhu, Gulibaha Maimaitili, Yi Ding, Weiran Li, Wei Liang, Zhibo Zhou, Qiang Wang, Feng Chen, Jiuxiang Lin. Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft. Protein Cell, 2024, 15(10): 783-789 DOI:10.1093/procel/pwae021

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