Single transmembrane GPCR modulating proteins: neither single nor simple

Meng Wang, Jianjun Lyu, Chao Zhang

PDF(9199 KB)
PDF(9199 KB)
Protein Cell ›› 2024, Vol. 15 ›› Issue (6) : 395-402. DOI: 10.1093/procel/pwad035
COMMENTARY

Single transmembrane GPCR modulating proteins: neither single nor simple

Author information +
History +

Cite this article

Download citation ▾
Meng Wang, Jianjun Lyu, Chao Zhang. Single transmembrane GPCR modulating proteins: neither single nor simple. Protein Cell, 2024, 15(6): 395‒402 https://doi.org/10.1093/procel/pwad035

References

[1]
Asai M, Ramachandrappa S, Joachim M et al. Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science 2013;341:275–278.
CrossRef Google scholar
[2]
Baron M, Maillet J, Huyvaert M et al. Loss-of-function mutations in MRAP2 are pathogenic in hyperphagic obesity with hyperglycemia and hypertension. Nat Med 2019;25:1733–1738.
CrossRef Google scholar
[3]
Chaly AL, Srisai D, Gardner EE et al. The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1. Elife 2016;5:e12397.
CrossRef Google scholar
[4]
Chan LF, Webb TR, Chung TT et al. MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci U S A 2009;106:6146–6151.
CrossRef Google scholar
[5]
Chen V, Bruno AE, Britt LL et al. Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2. J Biol Chem 2020;295:16370–16379.
CrossRef Google scholar
[6]
Chida D, Nakagawa S, Nagai S et al. Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis. Proc Natl Acad Sci U S A 2007;104:18205–18210.
CrossRef Google scholar
[7]
Chung TT, Chan LF, Metherell LA et al. Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2. Clin Endocrinol (Oxf) 2010;72:589–594.
CrossRef Google scholar
[8]
Hauser AS, Attwood MM, Rask-Andersen M et al. Trends in GPCR drug discovery: new agents, targets and indications. Nat Rev Drug Discov 2017;16:829–842.
CrossRef Google scholar
[9]
Jain V, Metherell LA, David A et al. Neonatal presentation of familial glucocorticoid deficiency resulting from a novel splice mutation in the melanocortin 2 receptor accessory protein. Eur J Endocrinol 2011;165:987–991.
CrossRef Google scholar
[10]
Kotliar IB, Lorenzen E, Schwenk JM et al. Elucidating the interactome of G protein-coupled receptors and receptor activity-modifying proteins. Pharmacol Rev 2023;75:1–34.
CrossRef Google scholar
[11]
Krishna Kumar K, O’Brien ES, Habrian CH et al. Negative allosteric modulation of the glucagon receptor by RAMP2. Cell 2023;186:1465–1477.e1418.
CrossRef Google scholar
[12]
Li L, Liang J, Zhang C et al. Peripheral actions and direct central-local communications of melanocortin 4 receptor signaling. J Sport Health Sci. 2021.
[13]
Liang J, Li L, Jin X et al. Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors. Endocrine 2018;61:94–104.
CrossRef Google scholar
[14]
Lorenzen E, Dodig-Crnković T, Kotliar IB et al. Multiplexed analysis of the secretin-like GPCR-RAMP interactome. Sci Adv 2019;5:eaaw2778.
CrossRef Google scholar
[15]
Luo P, Feng W, Ma S et al. Structural basis of signaling regulation of the human melanocortin-2 receptor by MRAP1. Cell Res 2023;33:46–54.
CrossRef Google scholar
[16]
Mailankody S, Devlin SM, Landa J et al. GPRC5D-targeted CAR T cells for myeloma. N Engl J Med 2022;387:1196–1206.
CrossRef Google scholar
[17]
McLatchie LM, Fraser NJ, Main MJ et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 1998;393:333–339.
CrossRef Google scholar
[18]
Metherell LA, Chapple JP, Cooray S et al. Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Nat Genet 2005;37:166–170.
CrossRef Google scholar
[19]
Novoselova TV, Hussain M, King PJ et al. MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. FASEB J 2018;32:fj201701274RR.
CrossRef Google scholar
[20]
Poyner DR, Sexton PM, Marshall I et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 2002;54:233–246.
CrossRef Google scholar
[21]
Rao YZ, Chen R, Zhang Y et al. Orange-spotted grouper melanocortin- 4 receptor: modulation of signaling by MRAP2. Gen Comp Endocrinol 2019;284:113234.
CrossRef Google scholar
[22]
Rouault AAJ, Lee AA, Sebag JA. Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling. Biochim Biophys Acta Mol Cell Res 2017;1864:2322–2329.
CrossRef Google scholar
[23]
Roy S, Rached M, Gallo-Payet N. Differential regulation of the human adrenocorticotropin receptor [melanocortin-2 receptor (MC2R)] by human MC2R accessory protein isoforms alpha and beta in isogenic human embryonic kidney 293 cells. Mol Endocrinol 2007;21:1656–1669.
CrossRef Google scholar
[24]
Sebag JA, Hinkle PM. Melanocortin-2 receptor accessory protein MRAP forms antiparallel homodimers. Proc Natl Acad Sci U S A 2007;104:20244–20249.
CrossRef Google scholar
[25]
Sebag JA, Hinkle PM. Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2. Sci Signal 2010;3:ra28.
CrossRef Google scholar
[26]
Sebag JA, Zhang C, Hinkle PM et al. Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish. Science 2013;341:278–281.
CrossRef Google scholar
[27]
Serafin DS, Harris NR, Nielsen NR et al. Dawn of a new RAMPage. Trends Pharmacol Sci 2020;41:249–265.
CrossRef Google scholar
[28]
Shao L, Chen Y, Zhang S et al. Modulating effects of RAMPs on signaling profiles of the glucagon receptor family. Acta Pharm Sin B 2022;12:637–650.
CrossRef Google scholar
[29]
Srisai D, Yin TC, Lee AA et al. MRAP2 regulates ghrelin receptor signaling and hunger sensing. Nat Commun 2017;8:713.
CrossRef Google scholar
[30]
Tai X, Xue S, Zhang C et al. Pharmacological evaluation of MRAP proteins on Xenopus neural melanocortin signaling. J Cell Physiol 2021;236:6344–6361.
CrossRef Google scholar
[31]
Wang M, Pi L, Lei X et al. Functional characterization of the internal symmetry of MRAP2 antiparallel homodimer. Front Endocrinol (Lausanne) 2021;12:750797.
CrossRef Google scholar
[32]
Wang M, Wang X, Jiang B et al. Identification of MRAP protein family as broad-spectrum GPCR modulators. Clin Transl Med 2022a;12:e1091.
CrossRef Google scholar
[33]
Wang M, Xu J, Lei XW et al. Selective interactions of mouse melanocortin receptor accessory proteins with somatostatin receptors. Cells 2022b;11:267.
CrossRef Google scholar
[34]
Wang M, Zhai Y, Lei X et al. Determination of the interaction and pharmacological modulation of MCHR1 signaling by the C-terminus of MRAP2 protein. Front Endocrinol (Lausanne) 2022c;13:848728.
CrossRef Google scholar
[35]
Wang X, Xue S, Lei X et al. Pharmacological evaluation of melanocortin 2 receptor accessory protein 2 on axolotl neural melanocortin signaling. Front Endocrinol (Lausanne) 2022d;13:820896.
CrossRef Google scholar
[36]
Wen ZY, Liu T, Qin CJ et al. MRAP2 interaction with melanocortin- 4 receptor in Snake Head (Channa argus). Biomolecules 2021;11:481.
CrossRef Google scholar
[37]
Xu J, Wang M, Fu Y et al. Reversion of MRAP2 protein sequence generates a functional novel pharmacological modulator for MC4R signaling. Biology (Basel) 2022;11(6):874.
CrossRef Google scholar
[38]
Zhang J, Li X, Zhou Y et al. The interaction of MC3R and MC4R with MRAP2, ACTH, α-MSH and AgRP in chickens. J Endocrinol 2017;234:155–174.
CrossRef Google scholar
[39]
Zhu M, Wang M, Chen Y et al. Pharmacological modulation of two melanocortin-5 receptors by MRAP2 proteins in zebrafish. J Mol Endocrinol 2018;62:27–36.
CrossRef Google scholar
[40]
Zhu M, Xu B, Wang M et al. Pharmacological modulation of MRAP2 protein on melanocortin receptors in the sea lamprey. Endocr Connect 2019;8:378–388.
CrossRef Google scholar

RIGHTS & PERMISSIONS

2023 The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.
AI Summary AI Mindmap
PDF(9199 KB)

Accesses

Citations

Detail

Sections
Recommended

/