Cryo-EM structures of a prokaryotic heme transporter CydDC

Chen Zhu; Yanfeng Shi; Jing Yu; Wenhao Zhao; Lingqiao Li; Jingxi Liang; Xiaolin Yang; Bing Zhang; Yao Zhao; Yan Gao; Xiaobo Chen; Xiuna Yang; Lu Zhang; Luke W. Guddat; Lei Liu; Haitao Yang; Zihe Rao; Jun Li

doi:10.1093/procel/pwad022

Protein Cell ›› 2023, Vol. 14 ›› Issue (12) : 919 -923. DOI: 10.1093/procel/pwad022

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Cryo-EM structures of a prokaryotic heme transporter CydDC

Chen Zhu ¹^,²
, Yanfeng Shi ¹
, Jing Yu ¹
, Wenhao Zhao ¹
, Lingqiao Li ¹
, Jingxi Liang ⁴
, Xiaolin Yang ¹^,²
, Bing Zhang ¹
, Yao Zhao ¹^,²
, Yan Gao ¹
, Xiaobo Chen ¹
, Xiuna Yang ¹
, Lu Zhang ¹
, Luke W. Guddat ⁶
, Lei Liu ²
, Haitao Yang ¹^,^†
, Zihe Rao ¹^,²^,³^,⁴^,⁵^,^†
, Jun Li ¹^,²^,^†

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Chen Zhu, Yanfeng Shi, Jing Yu, Wenhao Zhao, Lingqiao Li, Jingxi Liang, Xiaolin Yang, Bing Zhang, Yao Zhao, Yan Gao, Xiaobo Chen, Xiuna Yang, Lu Zhang, Luke W. Guddat, Lei Liu, Haitao Yang, Zihe Rao, Jun Li. Cryo-EM structures of a prokaryotic heme transporter CydDC. Protein Cell, 2023, 14(12): 919-923 DOI:10.1093/procel/pwad022

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References

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[1]	Borisov VB, Gennis RB, Hemp J et al. The cytochrome bd respiratory oxygen reductases. Biochim Biophys Acta 2011;1807: 1398–1413.

[2]	Cook GM, Poole RK. Oxidase and periplasmic cytochrome assembly in Escherichia coli K-12: CydDC and CcmAB are not required for haem–membrane association. Microbiology (Reading) 2000;146:527–536.

[3]	Cook GM, Cruz-Ramos H, Moir AJG et al. A novel haem compound accumulated in Escherichia coli overexpressing the cydDC operon, encoding an ABC-type transporter required for cytochrome assembly. Arch Microbiol 2002;178:358–369.

[4]	Georgiou CD, Fang H, Gennis RB. Identification of the cydC locus required for expression of the functional form of the cytochrome d terminal oxidase complex in Escherichia coli. J Bacteriol 1987;169:2107–2112.

[5]	Gong H, Gao Y, Zhou X et al. Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF. Nat Commun 2020;11:4245.

[6]	Gong H, Li J, Xu A et al. An electron transfer path connects subunits of a mycobacterial respiratory supercomplex. Science 2018;362:eaat8923.

[7]	Lyu J, Liu C, Zhang T et al. Structural basis for lipid and copper regulation of the ABC transporter MsbA. Nat Commun 2022;13:7291.

[8]	Poole RK, Cozens AG, Shepherd M. The CydDC family of transporters. Res Microbiol 2019;170:407–416.

[9]	Poole RK, Williams HD, Downie JA et al. Mutations affecting the cytochrome d-containing oxidase complex of Escherichia coli K12: identification and mapping of a fourth locus, cydD. J Gen Microbiol 1989;135:1865–1874.

[10]	Thomas C, Tampe R. Structural and mechanistic principles of ABC transporters. Annu Rev Biochem 2020;89:605–636.

[11]	Wang W, Gao Y, Tang Y et al. Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels. Nat Commun 2021;12:4621.

[12]	Ward A, Reyes Christopher L, Yu J et al. Flexibility in the ABC transporter MsbA: alternating access with a twist. Proc Natl Acad Sci USA 2007;104:19005–19010.

[13]	Wu D, Mehdipour AR, Finke F et al. Dissecting the conformational complexity and flipping mechanism of a prokaryotic heme transporter. bioRxiv 2022, preprint: not peer reviewed.

[14]	Yamashita M, Shepherd M, Booth Wesley I et al. Structure and function of the bacterial heterodimeric ABC transporter CydDC: stimulation of ATPase activity by thiol and heme compounds. J Biol Chem 2014;289:23177–23188.

[15]	Zhou X, Gao Y, Wang W et al. Architecture of the mycobacterial succinate dehydrogenase with a membrane-embedded Rieske FeS cluster. Proc Natl Acad Sci USA 2021;118:e2022308118.