APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation

Hongkai Zhao; Kuan Yang; Yiyuan Zhang; Hongyu Li; Qianzhao Ji; Zeming Wu; Shuai Ma; Si Wang; Moshi Song; Guang-Hui Liu; Qiang Liu; Weiqi Zhang; Jing Qu

doi:10.1093/procel/pwad017

Protein Cell ›› 2023, Vol. 14 ›› Issue (12) : 908 -913. DOI: 10.1093/procel/pwad017

LETTER

APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation

Hongkai Zhao ¹^,²
, Kuan Yang ³^,⁴^,¹⁰
, Yiyuan Zhang ²^,⁶^,⁷
, Hongyu Li ³^,⁶
, Qianzhao Ji ³^,⁶
, Zeming Wu ²^,⁵^,⁶^,⁷
, Shuai Ma ³^,⁵^,⁶^,⁷
, Si Wang ⁸^,⁹
, Moshi Song ³^,⁵^,⁶^,⁷
, Guang-Hui Liu ³^,⁵^,⁶^,⁷^,⁸^,⁹^,¹¹^,^†
, Qiang Liu ¹^,¹²^,¹³^,¹⁴^,¹⁵^,^†
, Weiqi Zhang ³^,⁴^,¹⁰^,¹¹^,^†
, Jing Qu ¹^,²^,³^,⁵^,⁷^,¹¹^,^†

Author information +

¹. Division of Life Sciences and Medicine, School of Life Sciences, University of Science and Technology of China, Hefei 230001, China

². State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

³. University of Chinese Academy of Sciences, Beijing 100049, China

⁴. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China

⁵. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

⁶. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

⁷. Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China

⁸. Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

⁹. Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

¹⁰. Sino-Danish College, University of Chinese Academy of Sciences, Beijing 101408, China

¹¹. Aging Biomarker Consortium, Beijing 100101, China

¹². Division of Life Sciences and Medicine, Institute on Aging and Brain Disorders, The First Affiliated Hospital of USTC, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China

¹³. Neurodegenerative Disease Research Center, University of Science and Technology of China, Hefei 230026, China

¹⁴. CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei 230026, China

¹⁵. Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650201, China

ghliu@ioz.ac.cn

liuq2012@ustc.edu.cn

zhangwq@big.ac.cn

qujing@ioz.ac.cn

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Hongkai Zhao, Kuan Yang, Yiyuan Zhang, Hongyu Li, Qianzhao Ji, Zeming Wu, Shuai Ma, Si Wang, Moshi Song, Guang-Hui Liu, Qiang Liu, Weiqi Zhang, Jing Qu. APOE-mediated suppression of the lncRNA MEG3 protects human cardiovascular cells from chronic inflammation. Protein Cell, 2023, 14(12): 908-913 DOI:10.1093/procel/pwad017

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