
Structural basis of INTAC-regulated transcription
Hai Zheng, Qianwei Jin, Xinxin Wang, Yilun Qi, Weida Liu, Yulei Ren, Dan Zhao, Fei Xavier Chen, Jingdong Cheng, Xizi Chen, Yanhui Xu
Protein Cell ›› 2023, Vol. 14 ›› Issue (9) : 698-702.
Structural basis of INTAC-regulated transcription
[1] |
Chen X, Qi Y, Wu Z et al. Structural insights into preinitiation complex assembly on core promoters. Science 2021;372:eaba8490.
CrossRef
Google scholar
|
[2] |
Core L, Adelman K. Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation. Genes Dev 2019;33:960–982.
CrossRef
Google scholar
|
[3] |
Ebmeier CC, Erickson B, Allen BL et al. Human TFIIH kinase CDK7 regulates transcription-associated chromatin modifications. Cell Rep 2017;20:1173–1186.
CrossRef
Google scholar
|
[4] |
Fianu I, Chen Y, Dienemann C et al. Structural basis of integrator-mediated transcription regulation. Science 2021;374:883–887.
CrossRef
Google scholar
|
[5] |
Harlen KM, Churchman LS. The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain. Nat Rev Mol Cell Biol 2017;18:263–273.
CrossRef
Google scholar
|
[6] |
Huang, KL, Jee, D, Stein, CB et al. Integrator recruits protein phosphatase 2A to prevent pause release and facilitate transcription termination. Mol Cell 2020;80:345–358.e9.
CrossRef
Google scholar
|
[7] |
Kamieniarz-Gdula K, Proudfoot NJ. Transcriptional control by premature termination: a forgotten mechanism. Trends Genet 2019;35:553–564.
CrossRef
Google scholar
|
[8] |
Pfleiderer, MM, Galej, WP. Structure of the catalytic core of the Integrator complex. Mol Cell 2021;81:1246–1259.e8.
CrossRef
Google scholar
|
[9] |
Skaar JR, Ferris AL, Wu X et al. The Integrator complex controls the termination of transcription at diverse classes of gene targets. Cell Res 2015;25:288–305.
CrossRef
Google scholar
|
[10] |
Stadelmayer B, Micas G, Gamot A et al. Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes. Nat Commun 2014;5:5531.
CrossRef
Google scholar
|
[11] |
Sun Y, Zhang Y, Aik WS et al. Structure of an active human histone premRNA 3’-end processing machinery. Science 2020;367:700–703.
CrossRef
Google scholar
|
[12] |
Vos SM, Farnung L, Urlaub H et al. Structure of paused transcription complex Pol II-DSIF-NELF. Nature 2018;560:601–606.
CrossRef
Google scholar
|
[13] |
Xu Y, Xing Y, Chen Y et al. Structure of the protein phosphatase 2A holoenzyme. Cell 2006;127:1239–1251.
CrossRef
Google scholar
|
[14] |
Yamamoto J, Hagiwara Y, Chiba K et al. DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes. Nat Commun 2014;5:4263.
CrossRef
Google scholar
|
[15] |
Zheng H, Qi Y, Hu S et al. Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase. Science 2020;370:eabb5872.
CrossRef
Google scholar
|
Supplementary files
PAC-0698-23075-XYH_suppl_1 (13019 KB)
PAC-0698-23075-XYH_suppl_2 (4943 KB)
PAC-0698-23075-XYH_suppl_3 (8667 KB)
PAC-0698-23075-XYH_suppl_4 (12969 KB)
PAC-0698-23075-XYH_suppl_5 (11722 KB)
/
〈 |
|
〉 |