Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model

Chun-Jie Liu; Hua-Yi Li; Yue Gao; Gui-Yan Xie; Jian-Hua Chi; Gui-Ling Li; Shao-Qing Zeng; Xiao-Ming Xiong; Jia-Hao Liu; Lin-Li Shi; Xiong Li; Xiao-Dong Cheng; Kun Song; Ding Ma; An-Yuan Guo; Qing-Lei Gao

doi:10.1093/procel/pwac053

Protein Cell ›› 2023, Vol. 14 ›› Issue (8) : 618 -622. DOI: 10.1093/procel/pwac053

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Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model

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¹. Department of Gynecological Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

². National Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

³. Center for Artificial Intelligence Biology, Hubei Bioinformatics & Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

⁴. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

⁵. Department of Gynecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

⁶. Department of Gynecological Oncology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310011, China

⁷. Gynecological Oncology Key Laboratory, Qilu Hospital, Shandong University, Jinan 250100, China

guoay@hust.edu.cn

qingleigao@hotmail.com

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Chun-Jie Liu, Hua-Yi Li, Yue Gao, Gui-Yan Xie, Jian-Hua Chi, Gui-Ling Li, Shao-Qing Zeng, Xiao-Ming Xiong, Jia-Hao Liu, Lin-Li Shi, Xiong Li, Xiao-Dong Cheng, Kun Song, Ding Ma, An-Yuan Guo, Qing-Lei Gao. Platelet RNA signature independently predicts ovarian cancer prognosis by deep learning neural network model. Protein Cell, 2023, 14(8): 618-622 DOI:10.1093/procel/pwac053

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References

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[1]	Best M, Sol N, Kooi I et al. RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics. Cancer Cell 2015;28:666–676.

[2]	Cho M, Bottsford-Miller J, Vasquez H et al. Platelets increase the proliferation of ovarian cancer cells. Blood 2012;120:4869–4872.

[3]	Chrzanowska-Wodnicka M, Smyth SS, Schoenwaelder SM et al. Rap1b is required for normal platelet function and hemostasis in mice. J Clin Invest 2005;115:680–687.

[4]	De Kock L, Freson K. The (patho)biology of SRC kinase in platelets and megakaryocytes. Medicina (Kaunas) 2020;56:633.

[5]	Haemmerle M, Stone R, Menter D et al. The platelet lifeline to cancer: challenges and opportunities. Cancer Cell 2018;33:965–983.

[6]	Haemmerle M, Taylor M, Gutschner T et al. Platelets reduce anoikis and promote metastasis by activating YAP1 signaling. Nat Commun 2017;8:310.

[7]	Meinders M, Kulu DI, van de Werken HJ et al. Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Blood 2015;125:1957–1967.

[8]	Roweth HG, Battinelli EM. Lessons to learn from tumor-educated platelets. Blood 2021;137:3174–3180.

[9]	Siegel RL, Miller KD, Fuchs HE et al. Cancer statistics, 2022. CA Cancer J Clin 2022;72:7–33.

[10]	Stone R, Nick A, McNeish I et al. Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med 2012;366:610–618.

[11]	Vaughan S, Coward JI, Bast RC et al. Rethinking ovarian cancer: recommendations for improving outcomes. Nat Rev Cancer 2011;11:719–725.

[12]	Wang R, Stone R, Kaelber J et al. Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer. Proc Natl Acad Sci USA 2015;112:14266–14271.

[13]	Wersäll A, Williams CM, Brown E et al. Mouse platelet Ral GTPases control P-selectin surface expression, regulating platelet-leukocyte interaction. Arterioscler Thromb Vasc Biol 2018;38:787–800.

[14]	Xu L, Li X, Li X et al. RNA profiling of blood platelets noninvasively differentiates colorectal cancer from healthy donors and non-cancerous intestinal diseases: a retrospective cohort study. Genome Med 2022;14:26.