Gαi1/3 mediation of Akt-mTOR activation is important for RSPO3-induced angiogenesis

Gang Xu, Li-na Qi, Mei-qing Zhang, Xue-yun Li, Jin-long Chai, Zhi-qing Zhang, Xia Chen, Qian Wang, Ke-ran Li, Cong Cao

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Protein Cell ›› 2023, Vol. 14 ›› Issue (3) : 217-222. DOI: 10.1093/procel/pwac035
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Gαi1/3 mediation of Akt-mTOR activation is important for RSPO3-induced angiogenesis

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Gang Xu, Li-na Qi, Mei-qing Zhang, Xue-yun Li, Jin-long Chai, Zhi-qing Zhang, Xia Chen, Qian Wang, Ke-ran Li, Cong Cao. Gαi1/3 mediation of Akt-mTOR activation is important for RSPO3-induced angiogenesis. Protein Cell, 2023, 14(3): 217‒222 https://doi.org/10.1093/procel/pwac035

References

[1]
Aoki M , Mieda M , Ikeda T et al. R-spondin3 is required for mouse placental development. Dev Biol 2007; 301: 218- 226.
[2]
Bai JY , Li Y , Xue GH et al. Requirement of Galphai1 and Galphai3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response. Theranostics 2021; 11: 4894- 4909.
[3]
Bian ZJ , Shan HJ , Zhu YR et al. Identification of Galphai3 as a promising target for osteosarcoma treatment. Int J Biol Sci 2022; 18: 1508- 1520.
[4]
Cao C , Huang X , Han Y et al. Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the AktmTORC1 pathway. Sci Signal 2009; 2: ra17.
[5]
Chen Z , Zhang J , Yuan A et al. R-spondin3 promotes the tumor growth of choriocarcinoma JEG-3 cells. Am J Physiol Cell Physiol 2020; 318: C664- 674.
[6]
Gu H , Tu H , Liu L et al. RSPO3 is a marker candidate for predicting tumor aggressiveness in ovarian cancer. Ann Transl Med 2020; 8: 1351.
[7]
Jin YR , Yoon JK . The R-spondin family of proteins: emerging regulators of WNT signaling. Int J Biochem Cell Biol 2012; 44: 2278- 2287.
[8]
Kazanskaya O , Ohkawara B , Heroult M et al. The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. Development 2008; 135: 3655- 3664.
[9]
Liu YY , Chen MB , Cheng L et al. microRNA-200a downregulation in human glioma leads to Galphai1 over-expression, Akt activation, and cell proliferation. Oncogene 2018; 37: 2890- 2902.
[10]
Marshall J , Zhou XZ , Chen G et al. Antidepression action of BDNF requires and is mimicked by Galphai1/3 expression in the hippocampus. Proc Natl Acad Sci USA 2018; 115: E3549- 3558.
[11]
Sun J , Huang W , Yang SF et al. Galphai1 and Galphai3mediate VEGFinduced VEGFR2 endocytosis, signaling and angiogenesis. Theranostics 2018; 8: 4695- 4709.
[12]
Tocci JM , Felcher CM , Garcia Sola ME et al. R-spondin-mediated WNT signaling potentiation in mammary and breast cancer development. IUBMB Life 2020; 72: 1546- 1559.
[13]
Wang Y , Liu YY , Chen MB et al. Neuronal-driven glioma growth requires Galphai1 and Galphai3. Theranostics 2021; 11: 8535- 8549.
[14]
Yao J , Wu XY , Yu Q et al. The requirement of phosphoenolpyruvate carboxykinase 1 for angiogenesis in vitro and in vivo. Sci Adv 2022; 8: eabn6928.
[15]
Zhang YM , Zhang ZQ , Liu YY et al. Requirement of Galphai1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3KAKT-mTORC1 activation. J Invest Dermatol 2015; 135: 181- 191.

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2022 The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.
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