Determiners of cell fates: the tricarboxylic acid cycle versus the citrate-malate shuttle

References

[1] Arnold PK , Jackson BT , Paras KI et al. A non-canonical tricarboxylic acid cycle underlies cellular identity. Nature 2022; 603: 477- 481.

[2] Assmann N , O’Brien KL , Donnelly RP et al. Srebp-controlled glucose metabolism is essential for NK cell functional responses. Nat Immunol 2017; 18: 1197- 1206.

[3] Borst P . The malate-aspartate shuttle (Borst cycle): how it started and developed into a major metabolic pathway. IUBMB Life 2020; 72: 2241- 2259.

[4] Chakrabarty RP , Chandel NS . Mitochondria as signaling organelles control mammalian stem cell fate. Cell Stem Cell 2021; 28: 394- 408.

[5] Chen PH , Cai L , Huffman K et al. Metabolic diversity in human non-small cell lung cancer cells. Mol Cell 2019; 76: 838- 851.

[6] Ferre P , Foufelle F . SREBP-1c transcription factor and lipid homeostasis: clinical perspective. Horm Res 2007; 68: 72- 82.

[7] Hatzivassiliou G , Zhao F , Bauer DE et al. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 2005; 8: 311- 321.

[8] Krebs HA , Johnson WA . Metabolism of ketonic acids in animal tissues. Biochem J 1937; 31: 645- 660.

[9] Lei C , Chen J , Li H et al. Role of the mitochondrial citrate-malate shuttle in Hras12V-induced hepatocarcinogenesis: a metabolomics-based analysis. Metabolites 2020; 10: 193.

[10] Li X , Jiang Y , Meisenhelder J et al. Mitochondria-translocated PGK1 functions as a protein kinase to coordinate glycolysis and the TCA cycle in tumorigenesis. Mol Cell 2016; 61: 705- 719.

[11] Liu R , Lee JH , Li J et al. Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. Mol Cell 2021; 81: 2722- 2735.

[12] Zhang J , Pavlova NN , Thompson CB . Cancer cell metabolism: the essential role of the nonessential amino acid, glutamine. EMBO J 2017; 36: 1302- 1315.

RIGHTS & PERMISSIONS

2022 The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.