Suppression of USP8 sensitizes cells to ferroptosis via SQSTM1/p62-mediated ferritinophagy

References

[1] Alvarez SW, Sviderskiy VO, Terzi EM et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature 2017; 5517682: 639- 43.

[2] Dixon SJ, Lemberg KM, Lamprecht MR et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012; 1495: 1060- 72.

[3] Dixon SJ, Stockwell BR. The role of iron and reactive oxygen species in cell death. Nat Chem Biol 2014; 101: 9- 17.

[4] Gao M, Monian P, Pan Q et al. Ferroptosis is an autophagic cell death process. Cell Res 2016; 269: 1021- 32.

[5] Hassannia B, Vandenabeele P, Vanden Berghe T. Targeting ferroptosis to iron out cancer. Cancer Cell 2019; 356: 830- 49.

[6] Islam MT, Chen F, Chen H. The oncogenic role of ubiquitin specific peptidase (USP8) and its signaling pathways targeting for cancer therapeutics. Arch Biochem Biophys 2021; 701: 108811.

[7] Liu T, Jiang L, Tavana O, Gu W. The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11. Cancer Res 2019; 798: 1913- 24.

[8] Ma ZY, Song ZJ, Chen JH et al. Recurrent gain-of-function USP8 mutations in Cushing’s disease. Cell Res 2015; 253: 306- 17.

[9] Mancias JD, Wang X, Gygi SP et al. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature 2014; 5097498: 105- 109.

[10] Peng H, Yang F, Hu Q et al. The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity. Autophagy 2019; 1- 11.

[11] Protchenko O, Baratz E, Jadhav S et al. Iron chaperone poly rC binding protein 1 protects mouse liver from lipid peroxidation and steatosis. Hepatology (Baltimore, Md.) 2021; 173: 1176- 1193.

[12] Shen J, Sheng X, Chang Z et al. Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. Cell Rep 2014; 71: 180- 193.

[13] Torti SV, DHM , Paul BT, Blanchette-Farra N, Torti FM. Iron and cancer. Annu Rev Nutr 2018; 38: 97- 125.

[14] Wang W, Green M, Choi JE et al. CD8(+) T cells regulate tumour ferroptosis during cancer immunotherapy. Nature 2019; 5697755: 270- 74.

[15] Zhang Y, Shi J, Liu X et al. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol 2018; 2010: 1181- 1192.

RIGHTS & PERMISSIONS

The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.