mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells

Qun Chu, Feifei Liu, Yifang He, Xiaoyu Jiang, Yusheng Cai, Zeming Wu, Kaowen Yan, Lingling Geng, Yichen Zhang, Huyi Feng, Kaixin Zhou, Si Wang, Weiqi Zhang, Guang-Hui Liu, Shuai Ma, Jing Qu, Moshi Song

PDF(993 KB)
PDF(993 KB)
Protein Cell ›› 2022, Vol. 13 ›› Issue (9) : 676-682. DOI: 10.1007/s13238-021-00898-9
LETTER
LETTER

mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells

Author information +
History +

Cite this article

Download citation ▾
Qun Chu, Feifei Liu, Yifang He, Xiaoyu Jiang, Yusheng Cai, Zeming Wu, Kaowen Yan, Lingling Geng, Yichen Zhang, Huyi Feng, Kaixin Zhou, Si Wang, Weiqi Zhang, Guang-Hui Liu, Shuai Ma, Jing Qu, Moshi Song. mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells. Protein Cell, 2022, 13(9): 676‒682 https://doi.org/10.1007/s13238-021-00898-9

References

[1]
BantugGR, Fischer M, GrahlertJ, BalmerML, Unterstab G, DeveliogluL, SteinerR, ZhangL, CostaASH, Gubser PM et al (2018) Mitochondria-endoplasmic reticulum contact sites function as immunometabolic hubs that orchestrate the rapid recall response of memory CD8(+) T cells. Immunity 48:542–555.e6
CrossRef Google scholar
[2]
BiS, LiuZ, WuZ, WangZ, LiuX, WangS, RenJ, YaoY, ZhangW, Song M et al (2020) SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell 11:483–504
CrossRef Google scholar
[3]
de Jesus DominguesAM, Artegiani B, DahlA, CalegariF (2016) Identification of Tox chromatin binding properties and down-stream targets by DamID-Seq. Genom Data 7:264–268
CrossRef Google scholar
[4]
Garcia-PratL, Sousa-Victor P, Munoz-CanovesP (2017) Proteostatic and metabolic control of stemness. Cell Stem Cell 20:593–608
CrossRef Google scholar
[5]
GuW, GaetaX, SahakyanA, Chan AB, HongCS, KimR, BraasD, PlathK, Lowry WE, ChristofkHR (2016) Glycolytic metabolism plays a functional role in regulating human pluripotent stem cell state. Cell Stem Cell 19:476–490
CrossRef Google scholar
[6]
HuJ, SunF, ChenW, Zhang J, ZhangT, QiM, FengT, LiuH, LiX, XingY et al (2019) BTF3 sustains cancer stem-like phenotype of prostate cancer via stabilization of BMI1. J Exp Clin Cancer Res 38:227
CrossRef Google scholar
[7]
MandalS, Lindgren AG, SrivastavaAS, ClarkAT, Banerjee U (2011) Mitochondrial function controls proliferation and early differentiation potential of embryonic stem cells. Stem Cells 29:486–495
CrossRef Google scholar
[8]
MengD, FrankAR, JewellJL (2018) mTOR signaling in stem and progenitor cells. Development 145(1):dev152595
CrossRef Google scholar
[9]
SchreiberKH, Arriola Apelo SI, YuD, BrinkmanJA, Velarde MC, SyedFA, LiaoCY, BaarEL, CarbajalKA, Sherman DS et al (2019) A novel rapamycin analog is highly selective for mTORC1 in vivo. Nat Commun 10:3194
CrossRef Google scholar
[10]
ShanH, GengL, JiangX, Song M, WangJ, LiuZ, ZhuoX, WuZ, HuJ, JiZ et al (2021) Large-scale chemical screen identifies gallic acid as a geroprotector for human stem cells. Protein Cell.
CrossRef Google scholar
[11]
WangJD, ShaoY, LiuD, LiuNY, ZhuDY (2021a) Rictor/mTORC2 involves mitochondrial function in ES cells derived cardiomyocytes via mitochondrial Connexin 43. Acta Pharmacol Sin.
CrossRef Google scholar
[12]
WangS, ChengF, JiQ, SongM, WuZ, ZhangY, JiZ, FengH, BelmonteJCI, Zhou Q et al (2021b) Hyperthermia differentially affects specific human stem cells and their differentiated derivatives. Protein Cell.
CrossRef Google scholar
[13]
WangS, MinZ, JiQ, GengL, SuY, LiuZ, HuH, WangL, ZhangW, Suzuiki K et al (2020) Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction. Protein Cell 11:1–22
CrossRef Google scholar
[14]
ZhengB, WangJ, TangL, Tan C, ZhaoZ, XiaoY, GeR, ZhuD (2017) Involvement of Rictor/mTORC2 in cardiomyocyte differentiation of mouse embryonic stem cells in vitro. Int J Biol Sci 13:110–121
CrossRef Google scholar
[15]
ZhuY, WangP, ZhangL, Bai G, YangC, WangY, HeJ, ZhangZ, Zhu G, ZouD (2019) Superhero Rictor promotes cellular differentiation of mouse embryonic stem cells. Cell Death Differ 26:958–968
CrossRef Google scholar

RIGHTS & PERMISSIONS

2022 The Author(s) 2022
AI Summary AI Mindmap
PDF(993 KB)

Accesses

Citations

Detail

Sections
Recommended

/