Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis

References

[1] Angelico R, Grimaldi C, Gazia C, Saffioti MC, Manzia TM, Castellano A, Spada M (2019) How do synchronous lung metastases influence the surgical management of children with hepatoblastoma? An update and systematic review of the literature. Cancers (basel) 11:1693

[2] Driskill JH, Pan D (2021) The Hippo pathway in liver homeostasis and pathophysiology. Annu Rev Pathol 16:299–322

[3] Hu H, Gehart H, Artegiani B, Lopez-Iglesias C, Dekkers F, Basak O, van Es J, de Sousa C, Lopes SM, Begthel H, Korving J et al (2018) Long-term expansion of functional mouse and human hepatocytes as 3D organoids. Cell 175:1591–1606

[4] O’Neill AF, Towbin AJ, Krailo MD, Xia CH, Gao Y, McCarville MB, Meyers RL, McGahren ED, Tiao GM, Dunn SP et al (2017) Characterization of pulmonary metastases in children with hepatoblastoma treated on Children’s Oncology Group protocol AHEP0731 (the treatment of children with all stages of hepatoblastoma): a report from the Children’s Oncology Group. J Clin Oncol 35:3465

[5] Prior N, Hindley CJ, Rost F, Melendez E, Lau WWY, Gottgens B, Rulands S, Simons BD, Huch M (2019) Lgr5(+) stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool. Development 146:dev174557

[6] Sumazin P, Chen Y, Trevino LR, Sarabia SF, Hampton OA, Patel K, Mistretta TA, Zorman B, Thompson P, Heczey A et al (2017) Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups. Hepatology 65:104–121

[7] Sun L, Wang Y, Cen J, Ma X, Cui L, Qiu Z, Zhang Z, Li H, Yang RZ, Wang C et al (2019) Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes. Nat Cell Biol 21:1015–1026

[8] Sylvester KG, Colnot S (2014) Hippo/YAP, beta-catenin, and the cancer cell: a „menage a trois” in hepatoblastoma. Gastroenterology 147:562–565

[9] Tao J, Calvisi DF, Ranganathan S, Cigliano A, Zhou L, Singh S, Jiang L, Fan B, Terracciano L, Armeanu-Ebinger S et al (2014) Activation of beta-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice. Gastroenterology 147:690–701

[10] Zhang Y, Solinas A, Cairo S, Evert M, Chen X, Calvisi DF (2021) Molecular mechanisms of hepatoblastoma. Semin Liver Dis 41:28–41

[11] Zhao B, Wei X, Li W, Udan RS, Yang Q, Kim J, Xie J, Ikenoue T, Yu J, Li L et al (2007) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 21:2747–2761

RIGHTS & PERMISSIONS

The Author(s)