Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

Jinghui Lei; Xiaoyu Jiang; Wei Li; Jie Ren; Datao Wang; Zhejun Ji; Zeming Wu; Fang Cheng; Yusheng Cai; Zheng-Rong Yu; Juan Carlos Izpisua Belmonte; Chunyi Li; Guang-Hui Liu; Weiqi Zhang; Jing Qu; Si Wang

doi:10.1007/s13238-021-00860-9

PDF(934 KB)

Protein Cell ›› 2022, Vol. 13 ›› Issue (3) : 220-226. DOI: 10.1007/s13238-021-00860-9

LETTER

Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis

Jinghui Lei¹^,⁴ ,
Xiaoyu Jiang²^,⁸ ,
Wei Li¹^,⁴ ,
Jie Ren⁵^,⁶^,⁸^,¹⁰ ,
Datao Wang⁷ ,
Zhejun Ji³^,⁶^,¹¹ ,
Zeming Wu²^,⁶^,¹¹ ,
Fang Cheng⁸^,⁹ ,
Yusheng Cai²^,⁶^,¹¹ ,
Zheng-Rong Yu¹² ,
Juan Carlos Izpisua Belmonte¹³ ,
Chunyi Li⁷ ,
Guang-Hui Liu¹^,²^,⁶^,⁸^,¹¹ ,
Weiqi Zhang⁵^,⁶^,⁸^,¹⁰ ,
Jing Qu³^,⁶^,⁸^,¹¹ ,
Si Wang¹^,²^,⁴

Author information +

History +

Cite this article

EndNote

Ris (Procite)

Bibtex

Download citation ▾

Jinghui Lei, Xiaoyu Jiang, Wei Li, Jie Ren, Datao Wang, Zhejun Ji, Zeming Wu, Fang Cheng, Yusheng Cai, Zheng-Rong Yu, Juan Carlos Izpisua Belmonte, Chunyi Li, Guang-Hui Liu, Weiqi Zhang, Jing Qu, Si Wang. Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis. Protein Cell, 2022, 13(3): 220‒226 https://doi.org/10.1007/s13238-021-00860-9

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Yao Y, Zhang W, Song M(2020) SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell 11:483–504 CrossRef Google scholar

[2]	Geng L, Liu Z, Zhang W, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Sun L(2019) Chemical screen identifies a geroprotective role of quercetin in premature aging. Protein Cell 10:417–435 CrossRef Google scholar

[3]	Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N(2017) Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med 23:775–781 CrossRef Google scholar

[4]	Kalluri R, LeBleu VS(2020) The biology, function, and biomedical applications of exosomes. Science 367:eaau6977 CrossRef Google scholar

[5]	Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI(2021a) FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction. Protein Cell 12:145–151 CrossRef Google scholar

[6]	Lei Q, Gao F, Liu T, Ren W, Chen L, Cao Y, Chen W, Guo S, Zhang Q, Chen W(2021b) Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow-derived mesenchymal stem cells and slow age-related degeneration. Sci Transl Med 13:eaaz8697 CrossRef Google scholar

[7]	Rong X, Chu W, Zhang H, Wang Y, Qi X, Zhang G, Wang Y, Li C(2019) Antler stem cell-conditioned medium stimulates regenerative wound healing in rats. Stem Cell Res Ther 10:326 CrossRef Google scholar

[8]	Rong X, Yang Y, Zhang G, Zhang H, Li C, Wang Y (2020) Antler stem cells as a novel stem cell source for reducing liver fibrosis. Cell Tissue Res 379:195–206 CrossRef Google scholar

[9]	Sui Z, Sun H, Weng Y, Zhang X, Sun M, Sun R, Zhao B, Liang Z, Zhang Y, Li C(2020) Quantitative proteomics analysis of deer antlerogenic periosteal cells reveals potential bioactive factors in velvet antlers. J Chromatogr A 1609: CrossRef Google scholar

[10]	Tran C, Damaser MS(2015) Stem cells as drug delivery methods: application of stem cell secretome for regeneration. Adv Drug Deliv Rev 82–83:1–11 CrossRef Google scholar

[11]	Wang D, Berg D, Ba H, Sun H, Wang Z, Li C(2019) Deer antler stem cells are a novel type of cells that sustain full regeneration of a mammalian organ-deer antler. Cell Death Dis 10:443 CrossRef Google scholar

[12]	Xu M, Bradley EW, Weivoda MM, Hwang SM, Pirtskhalava T, Decklever T, Curran GL, Ogrodnik M, Jurk D, Johnson KO(2017) Transplanted senescent cells induce an osteoarthritis-like condition in mice. J Gerontol A 72:780–785 CrossRef Google scholar

[13]	Yao B, Zhang M, Leng X, Liu M, Liu Y, Hu Y, Zhao D, Zhao Y(2018) Antler extracts stimulate chondrocyte proliferation and possess potent anti-oxidative, anti-inflammatory, and immune-modulatory properties. In Vitro Cell Dev Biol Anim 54:439–448 CrossRef Google scholar

[14]	Yin K, Wang S, Zhao RC(2019) Exosomes from mesenchymal stem/stromal cells: a new therapeutic paradigm. Biomark Res 7:8 CrossRef Google scholar

[15]	Zhang J, Liu GH, Qu J, Song M(2020) Treating osteoarthritis via gene therapy with rejuvenation factors. Gene Ther 27:309–311 CrossRef Google scholar