METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth

Mengyue Lv, Dan Cao, Liwen Zhang, Chi Hu, Shukai Li, Panrui Zhang, Lianbang Zhu, Xiao Yi, Chaoliang Li, Alin Yang, Zhentao Yang, Yi Zhu, Kaiguang Zhang, Wen Pan

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Protein Cell ›› 2021, Vol. 12 ›› Issue (12) : 965-970. DOI: 10.1007/s13238-021-00857-4
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METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth

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Mengyue Lv, Dan Cao, Liwen Zhang, Chi Hu, Shukai Li, Panrui Zhang, Lianbang Zhu, Xiao Yi, Chaoliang Li, Alin Yang, Zhentao Yang, Yi Zhu, Kaiguang Zhang, Wen Pan. METTL9 mediated N1-histidine methylation of zinc transporters is required for tumor growth. Protein Cell, 2021, 12(12): 965‒970 https://doi.org/10.1007/s13238-021-00857-4

References

[1]
Adulcikas J, Norouzi S, Bretag L, Sohal SS, Myers S (2018) The zinc transporter SLC39A7 (ZIP7) harbours a highly-conserved his-tidine-rich N-terminal region that potentially contributes to zinc homeostasis in the endoplasmic reticulum. Comput Biol Med 100:196–202
CrossRef Google scholar
[2]
Al-Hadid Q, Roy K, Munroe W, Dzialo MC, Chanfreau GF, Clarke SG (2014) Histidine methylation of yeast ribosomal protein Rpl3p is required for proper 60S subunit assembly. Mol Cell Biol 34 (15):2903–2916
CrossRef Google scholar
[3]
Cao R, Zhang X, Liu X, Li Y, Li H(2018) Molecular basis for histidine N1 position-specific methylation by CARNMT1. Cell Res 28 (4):494–496
CrossRef Google scholar
[4]
Davydova E, Shimazu T, Schuhmacher MK, Jakobsson ME, Willemen HL, Liu T, Moen A, Ho AY, Małecki J, Schroer L (2021) The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nat Commun 12(1):891
CrossRef Google scholar
[5]
Guo Q, Liao S, Kwiatkowski S, Tomaka W, Yu H, Wu G, Tu X, Min J, Drozak J, Xu C (2019) Structural insights into SETD3-mediated histidine methylation on beta-actin. eLife 8:e43676
CrossRef Google scholar
[6]
Ignatova VV, Jansen P, Baltissen MP, Vermeulen M, Schneider R (2019) The interactome of a family of potential methyltrans-ferases in HeLa cells. Sci Rep 9(1):6584
CrossRef Google scholar
[7]
Jiang X, Liu B, Nie Z, Duan L, Xiong Q, Jin Z, Yang C, Chen Y (2021) The role of m6A modification in the biological functions and diseases. Signal Transduct Target Ther. 6(1):74
CrossRef Google scholar
[8]
Kwiatkowski S, Drozak J (2020) Protein histidine methylation. Curr Protein Pept Sci 21:675
CrossRef Google scholar
[9]
Kwiatkowski S, Seliga AK, Vertommen D, Terreri M, Ishikawa T, Grabowska I, Tiebe M, Teleman AA, Jagielski AK, Veiga-da-Cunha M (2018) SETD3 protein is the actin-specific histidine N-methyltransferase. eLife 7:e37929
CrossRef Google scholar
[10]
Ning Z, Star AT, Mierzwa A, Lanouette S, Mayne J, Couture JF, Figeys D (2016) A charge-suppressing strategy for probing protein methylation. Chem Commun 52(31):5474–5477
CrossRef Google scholar
[11]
Petrossian TC, Clarke SG (2011) Uncovering the human methyl-transferasome. Mol Cell Proteomics 10(1):M110000976
CrossRef Google scholar
[12]
Searle JM, Westall RG (1951) The occurrence of free methylhis-tidine in urine. Biochem J 48(5):R50-R
[13]
Webb KJ, Zurita-Lopez CI, Al-Hadid Q, Laganowsky A, Young BD, Lipson RS, Souda P, Faull KF, Whitelegge JP, Clarke SG (2010) A novel 3-methylhistidine modification of yeast ribosomal protein Rpl3 Is dependent upon the YIL110W methyltransferase. J Biol Chem 285(48):37598–37606
CrossRef Google scholar
[14]
Wilkinson AW, Diep J, Dai S, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C (2019) SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature 565 (7739):372–376
CrossRef Google scholar
[15]
Zhang T, Kuliyev E, Sui D, Hu J (2019) The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport. Biochem J 476(12):1791–1803
CrossRef Google scholar

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