Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine

Xingdong Zhou, Hui Wang, Qun Ji, Mingjuan Du, Yuexia Liang, Huanhuan Li, Fan Li, Hang Shang, Xiujuan Zhu, Wei Wang, Lichun Jiang, Alexey V. Stepanov, Tianyu Ma, Nanxin Gong, Xiaodong Jia, Alexander G. Gabibov, Zhiyong Lou, Yinying Lu, Yu Guo, Hongkai Zhang, Xiaoming Yang

PDF(704 KB)
PDF(704 KB)
Protein Cell ›› 2021, Vol. 12 ›› Issue (10) : 818-823. DOI: 10.1007/s13238-021-00840-z
LETTER
LETTER

Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine

Author information +
History +

Cite this article

Download citation ▾
Xingdong Zhou, Hui Wang, Qun Ji, Mingjuan Du, Yuexia Liang, Huanhuan Li, Fan Li, Hang Shang, Xiujuan Zhu, Wei Wang, Lichun Jiang, Alexey V. Stepanov, Tianyu Ma, Nanxin Gong, Xiaodong Jia, Alexander G. Gabibov, Zhiyong Lou, Yinying Lu, Yu Guo, Hongkai Zhang, Xiaoming Yang. Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine. Protein Cell, 2021, 12(10): 818‒823 https://doi.org/10.1007/s13238-021-00840-z

References

[1]
Anderson EJ, Rouphael NG, Widge AT, Jackson LA, Roberts PC, Makhene M, Chappell JD, Denison MR, Stevens LJ, Pruijssers AJ (2020) Safety and immunogenicity of SARS-CoV-2 mRNA-1273 vaccine in older adults. N Engl J Med 383:2427–2438
CrossRef Google scholar
[2]
Brouwer PJM, Caniels TG, van der Straten K, Snitselaar JL, Aldon Y, Bangaru S, Torres JL, Okba NMA, Claireaux M, Kerster G (2020) Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability. Science 369:643–650
CrossRef Google scholar
[3]
Cao Y, Su B, Guo X, Sun W, Deng Y, Bao L, Zhu Q, Zhang X, Zheng Y, Geng C (2020) Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput Single-cell sequencing of convalescent patients’ B cells. Cell 182:73–84
CrossRef Google scholar
[4]
Jones I, Roy P (2021) Sputnik V COVID-19 vaccine candidate appears safe and effective. Lancet. 397(10275):642–643
CrossRef Google scholar
[5]
Ju B, Zhang Q, Ge J, Wang R, Sun J, Ge X, Yu J, Shan S, Zhou B, Song S (2020) Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature 584:115–119
CrossRef Google scholar
[6]
Lerner RA (2006) Manufacturing immunity to disease in a test tube: the magic bullet realized. Angew Chem 45:8106–8125
CrossRef Google scholar
[7]
Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, Perez JL, Pérez Marc G, Moreira ED, Zerbini C (2020) Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med 383:2603–2615
CrossRef Google scholar
[8]
Rajan S, Kierny MR, Mercer A, Wu J, Tovchigrechko A, Wu H, Dall Acqua WF, Xiao X, Chowdhury PS (2018) Recombinant human B cell repertoires enable screening for rare, specific, and natively paired antibodies. Commun Biol 1:5
CrossRef Google scholar
[9]
von Boehmer L, Liu C, Ackerman S, Gitlin AD, Wang Q, Gazumyan A, Nussenzweig MC (2016) Sequencing and cloning of antigenspecific antibodies from mouse memory B cells. Nat Protoc 11:1908–1923
CrossRef Google scholar
[10]
Wang B, DeKosky BJ, Timm MR, Lee J, Normandin E, Misasi J, Kong R, McDaniel JR, Delidakis G, Leigh KE (2018) Functional interrogation and mining of natively paired human V (H):V(L) antibody repertoires. Nat Biotechnol 36:152–155
CrossRef Google scholar
[11]
Wang H, Zhang Y, Huang B, Deng W, Quan Y, Wang W, Xu W, Zhao Y, Li N, Zhang J (2020) Development of an inactivated vaccine candidate, BBIBP-CorV, with potent protection against SARS-CoV-2. Cell 182:713–721.e719
CrossRef Google scholar
[12]
Wang P, Liu L, Iketani S, Luo Y, Guo Y, Wang M, Yu J, Zhang B, Kwong PD, Graham BS (2021) Increased resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7 to antibody neutralization. bioRxiv, 2021.2001.2025.428137.
[13]
Wen GP, He L, Tang ZM, Wang SL, Zhang X, Chen YZ, Lin X, Liu C, Chen JX, Ying D (2020) Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans. Nat Commun 11:3971
CrossRef Google scholar
[14]
Wu S, Zhong G, Zhang J, Shuai L, Zhang Z, Wen Z, Wang B, Zhao Z, Song X, Chen Y (2020) A single dose of an adenovirusvectored vaccine provides protection against SARS-CoV-2 challenge. Nat Commun 11:4081
CrossRef Google scholar
[15]
Xia S, Zhang Y, Wang Y, Wang H, Yang Y, Gao GF, Tan W, Wu G, Xu M, Lou Z (2021) Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial. Lancet Infect Dis 21:39–51
CrossRef Google scholar

RIGHTS & PERMISSIONS

2021 The Author(s) 2021
AI Summary AI Mindmap
PDF(704 KB)

Accesses

Citations

Detail

Sections
Recommended

/