Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies

Hu Dong , Pan Liu , Manyuan Bai , Kang Wang , Rui Feng , Dandan Zhu , Yao Sun , Suyu Mu , Haozhou Li , Michiel Harmsen , Shiqi Sun , Xiangxi Wang , Huichen Guo

Protein Cell ›› 2022, Vol. 13 ›› Issue (6) : 446 -453.

PDF (4290KB)
Protein Cell ›› 2022, Vol. 13 ›› Issue (6) : 446 -453. DOI: 10.1007/s13238-021-00828-9
LETTER
LETTER

Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies

Author information +
History +
PDF (4290KB)

Cite this article

Download citation ▾
Hu Dong, Pan Liu, Manyuan Bai, Kang Wang, Rui Feng, Dandan Zhu, Yao Sun, Suyu Mu, Haozhou Li, Michiel Harmsen, Shiqi Sun, Xiangxi Wang, Huichen Guo. Structural and molecular basis for foot-and-mouth disease virus neutralization by two potent protective antibodies. Protein Cell, 2022, 13(6): 446-453 DOI:10.1007/s13238-021-00828-9

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Dang M , Wang X , Wang Q , Wang Y , Lin J , Sun Y , Li X , Zhang L , Lou Z , Wang J et al (2014) Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71. Protein & Cell 5: 692- 703

[2]

Harmsen MM , van Solt CB , Fijten HP , van Keulen L , Rosalia RA , Weerdmeester K , Cornelissen AH , De Bruin MG , Eble PL , Dekker A (2007) Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease. Vet Microbiol 120: 193- 206

[3]

Harmsen MM , Fijten HPD , Westra DF , Coco-Martin JM (2011) Effect of thiomersal on dissociation of intact (146S) foot-and-mouth disease virions into 12S particles as assessed by novel ELISAs specific for either 146S or 12S particles. Vaccine 29: 2682- 2690

[4]

Harmsen MM , Seago J , Perez E , Charleston B , Eble PL , Dekker A (2017) Isolation of single-domain antibody fragments that preferentially detect intact (146S) particles of foot-and-mouth disease virus for use in vaccine quality control. Front Immunol.

[5]

Kotecha A , Wang Q , Dong XC , Ilca SL , Ondiviela M , Zihe R , Seago J , Charleston B , Fry EE , Abrescia NGA , Springer TA , Huiskonen JT , Stuart DI (2017) Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus. Nat Commun 8: 8

[6]

Logan D , Abu-Ghazaleh R , Blakemore W , Curry S , Jackson T , King A , Lea S , Lewis R , Newman J , Parry N et al (1993) Structure of a major immunogenic site on foot-and-mouth disease virus. Nature 362: 566- 568

[7]

Juleff N , Windsor M , Lefevre EA , Gubbins S , Hamblin P , Reid E , McLaughlin K , Beverley PCL , Morrison IW , Charleston B (2009) Foot-and-mouth disease virus can induce a specific and rapid CD4(+) T-cell-independent neutralizing and isotype classswitched antibody response in Naive Cattle. J Virol 83: 3626- 3636

[8]

McCahon D , Crowther JR , Belsham GJ , Kitson JD , Duchesne M , Have P , Meloen RH , Morgan DO , De Simone F (1989) Evidence for at least four antigenic sites on type O foot-and-mouth disease virus involved in neutralization; identification by single and multiple site monoclonal antibody-resistant mutants. J Gen Virol 70(Pt 3): 639- 645

[9]

Pay TW , Hingley PJ (1987) Correlation of 140S antigen dose with the serum neutralizing antibody response and the level of protection induced in cattle by foot-and-mouth disease vaccines. Vaccine 5: 60- 64

[10]

Paton DJ , Sumption KJ , Charleston B (2009) Options for control of foot-and-mouth disease: knowledge, capability and policy. Philos Trans R Soc Lond B 364: 2657- 2667

[11]

SaCarvalho D , Rieder E , Baxt B , Rodarte R , Tanuri A , Mason PW (1997) Tissue culture adaptation of foot-and-mouth disease virus selects viruses that bind to heparin and are attenuated in cattle. J Virol 71: 5115- 5123

[12]

Qiu X , Lei Y , Yang P , Gao Q , Wang N , Cao L , Yuan S , Huang X , Deng Y , Ma W et al (2018) Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies. Nat Microbiol 3: 287- 294

[13]

Tuthill TJ , Groppelli E , Hogle JM , Rowlands DJ (2010) Picornaviruses. In: Cell entry by non-enveloped viruses. Springer, pp 43- 89

[14]

Wang N , Zhao D , Wang J , Zhang Y , Wang M , Gao Y , Li F , Wang J , Bu Z , Rao Z et al (2019) Architecture of African swine fever virus and implications for viral assembly. Science 366: 640- 644

[15]

Zhu L , Xu K , Wang N , Cao L , Wu J , Gao Q , Fry EE , Stuart DI , Rao Z , Wang J et al (2018) Neutralization mechanisms of two highly potent antibodies against human enterovirus 71. MBio 9: 66- 69

RIGHTS & PERMISSIONS

The Author(s)

AI Summary AI Mindmap
PDF (4290KB)

Supplementary files

PAC-0446-20960-WXX_suppl_1

606

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/