Single-cell transcriptomics of cardiac progenitors reveals functional subpopulations and their cooperative crosstalk in cardiac repair

Lei Gao; Hongjie Zhang; Jingyi Cui; Lijuan Pei; Shiqi Huang; Yaning Mao; Zhongmin Liu; Ke Wei; Hongming Zhu

doi:10.1007/s13238-020-00788-6

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Protein Cell ›› 2021, Vol. 12 ›› Issue (2) : 152-157. DOI: 10.1007/s13238-020-00788-6

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Single-cell transcriptomics of cardiac progenitors reveals functional subpopulations and their cooperative crosstalk in cardiac repair

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Lei Gao, Hongjie Zhang, Jingyi Cui, Lijuan Pei, Shiqi Huang, Yaning Mao, Zhongmin Liu, Ke Wei, Hongming Zhu. Single-cell transcriptomics of cardiac progenitors reveals functional subpopulations and their cooperative crosstalk in cardiac repair. Protein Cell, 2021, 12(2): 152‒157 https://doi.org/10.1007/s13238-020-00788-6

References

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[1]	Cambier L, de Couto G,Ibrahim A, Echavez AK, Valle J, Liu W, Kreke M, Smith RR, Marban L, Marban E (2017) Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL-10 expression and secretion. EMBO Mol Med 9:337–352 CrossRef Google scholar

[2]	Das S,Goldstone AB, Wang H, Farry J, D’Amato G,Paulsen MJ, Eskandari A,Hironaka CE, Phansalkar R, Sharma B (2019) A unique collateral artery development program promotes neonatal heart regeneration. Cell 176:1128–1142.e1118 CrossRef Google scholar

[3]	DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J,Pu W (2016) Single-cell resolution of temporal gene expression during heart development. Dev Cell 39:480–490 CrossRef Google scholar

[4]

Ellison GM, Torella D, Dellegrottaglie S, Perez-Martinez C, Perez de Prado A, Vicinanza C, Purushothaman S,Galuppo V, Iaconetti C, Waring CD (2011) Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection fosters survival and regeneration of the infarcted pig heart. J Am Coll Cardiol 58:977–986

CrossRef Google scholar

[5]	Ibrahim AGE, Li C, Rogers R, Fournier M, Li L, Vaturi SD, Antes T, Sanchez L, Akhmerov A, Moseley JJ (2019) Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories. Nat Biomed Eng 3:695–705 CrossRef Google scholar

[6]	Konemann S, Sartori LV, Gross S, Hadlich S, Kuhn JP, Samal R,Bahls M, Felix SB, Wenzel K (2019) Cardio-protective effect of the secretome of Sca-1+ and Sca-1− cells in heart failure—not equal, but equally important? Cardiovasc Res 116:566–575 CrossRef Google scholar

[7]	Menasché P (2018) Cell therapy trials for heart regeneration—lessons learned and future directions. Nat Rev Cardiol 15:659–671 CrossRef Google scholar

[8]	Sano T,Ousaka D, Goto T, Ishigami S, Hirai K, Kasahara S,Ohtsuki S, Sano S, Oh H(2018) Impact of cardiac progenitor cells on heart failure and survival in single ventricle congenital heart disease. Circ Res 122:994–1005 CrossRef Google scholar

[9]	Skelly DA, Squiers GT, McLellan MA, Bolisetty MT, Robson P, Rosenthal NA, Pinto AR (2018) Single-cell transcriptional profiling reveals cellular diversity and intercommunication in the mouse heart. Cell Rep 22:600–610 CrossRef Google scholar

[10]	Sun H, Zhou Y, Fei L, Chen H, Guo G (2019) scMCa: a tool to define mouse cell types based on single-cell digital expression. Methods Mol Biol 1935:91–96 CrossRef Google scholar

[11]	Tompkins BA, Balkan W, Winkler J, Gyongyosi M, Goliasch G, Fernandez-Aviles F,Hare JM (2018) Preclinical studies of stem cell therapy for heart disease. Circ Res 122:1006–1020 CrossRef Google scholar

[12]	Zhao ZA, Han X, Lei W, Li J, Yang Z, Wu J, Yao M, Lu XA, He L, Chen Y (2018) Lack of cardiac improvement after cardiosphere-derived cell transplantation in aging mouse hearts. Circ Res 123:e21–e31 CrossRef Google scholar