FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction

Jinghui Lei; Si Wang; Wang Kang; Qun Chu; Zunpeng Liu; Liang Sun; Yun Ji; Concepcion Rodriguez Esteban; Yan Yao; Juan Carlos Izpisua Belmonte; Piu Chan; Guang-Hui Liu; Weiqi Zhang; Moshi Song; Jing Qu

doi:10.1007/s13238-020-00779-7

Protein Cell ›› 2021, Vol. 12 ›› Issue (2) : 145 -151. DOI: 10.1007/s13238-020-00779-7

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FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction

Jinghui Lei ¹
, Si Wang ¹^,²^,⁵
, Wang Kang ⁴^,⁶
, Qun Chu ³
, Zunpeng Liu ³^,⁶
, Liang Sun ⁷
, Yun Ji ²^,⁵^,⁶
, Concepcion Rodriguez Esteban ⁹
, Yan Yao ⁸
, Juan Carlos Izpisua Belmonte ⁹
, Piu Chan ¹
, Guang-Hui Liu ¹^,²^,⁵^,⁶^,^†
, Weiqi Zhang ⁴^,⁵^,⁶^,^†
, Moshi Song ²^,⁵^,^†
, Jing Qu ³^,⁵^,⁶^,^†

Author information +

¹. Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China

². State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

³. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

⁴. Disease Genomics and Individualized Medicine Laboratory, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China

⁵. Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China

⁶. University of Chinese Academy of Sciences, Beijing 100049, China

⁷. The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing 100730, China

⁸. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

⁹. Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla 92037, USA

ghliu@ioz.ac.cn (G.-H. Liu)

zhangwq@big.ac.cn (W. Zhang)

songmoshi@ioz.ac.cn (M. Song)

qujing@ioz.ac.cn (J. Qu)

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Jinghui Lei, Si Wang, Wang Kang, Qun Chu, Zunpeng Liu, Liang Sun, Yun Ji, Concepcion Rodriguez Esteban, Yan Yao, Juan Carlos Izpisua Belmonte, Piu Chan, Guang-Hui Liu, Weiqi Zhang, Moshi Song, Jing Qu. FOXO3-engineered human mesenchymal progenitor cells efficiently promote cardiac repair after myocardial infarction. Protein Cell, 2021, 12(2): 145-151 DOI:10.1007/s13238-020-00779-7

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References

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[1]	Bagno L, Hatzistergos KE, Balkan W, Hare JM (2018) Mesenchymal stem cell-based therapy for cardiovascular disease: progress and challenges. Mol Ther 26:1610–1623

[2]	Block TJ, Marinkovic M, Tran ON, Gonzalez AO, Marshall A, Dean DD, Chen XD (2017) Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies. Stem Cell Res Ther 8:239

[3]	De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G,Adney EM, Boeke JD (2019) L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature 566:73–78

[4]	Gyongyosi M, Haller PM, Blake DJ, Martin ERendon (2018) Metaanalysis of cell therapy studies in heart failure and acute myocardial infarction. Circ Res 123:301–308

[5]	Kanelidis AJ, Premer C, Lopez J, Balkan W, Hare JM (2017) Route of delivery modulates the efficacy of mesenchymal stem cell therapy for myocardial infarction: a meta-analysis of preclinical studies and clinical trials. Circ Res 120:1139–1150

[6]	Le Blanc K, Davies LC (2018) MSCs-cells with many sides. Cytotherapy 20:273–278

[7]	Li L, Kang H, Zhang Q, D’Agati VD, Al-Awqati Q, Lin F (2019) FoxO3 activation in hypoxic tubules prevents chronic kidney disease. J Clin Investig 129:2374–2389

[8]	Li H, Wu Z, Liu X, Zhang S, Ji Q, Jiang X, Liu Z, Wang S, Qu J, Zhang W (2020) ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells. Protein Cell.

[9]	Lim SW, Jin L, Luo K, Jin J, Shin YJ, Hong SY, Yang CW (2017) Klotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress. Cell Death Dis 8: e2972

[10]	Liu Y, Ao X, Ding W, Ponnusamy M, Wu W, Hao X, Yu W, Wang Y, Li P, Wang J (2018) Critical role of FOXO3a in carcinogenesis. Mol Cancer 17:104

[11]	Nguyen PK, Neofytou E, Rhee JW, Wu JC (2016) Potential strategies to address the major clinical barriers facing stem cell regenerative therapy for cardiovascular disease: a review. JAMA Cardiol 1:953–962

[12]

Salazar-Noratto GE, Luo G, Denoeud C, Padrona M, Moya A, Bensidhoum M, Bizios R, Potier E, Logeart-Avramoglou D, Petite H (2020) Understanding and leveraging cell metabolism to enhance mesenchymal stem cell transplantation survival in tissue engineering and regenerative medicine applications. Stem Cells 38:22–23

[13]	Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, Li J, Chan P, Liu GH, Zhang W (2018) CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-kappaB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell 9:945–965

[14]	Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, He X, Wang S (2019) FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. Cell Stem Cell 24(447–461):e448

[15]	Zhang W, Zhang S, Yan P, Ren J, Song M, Li J, Lei J, Pan H, Wang S, Ma X (2020) A single-cell transcriptomic landscape of primate arterial aging. Nat Commun 11:2202