Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase

Yechun Xu, Hualiang Jiang

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Protein Cell ›› 2020, Vol. 11 ›› Issue (10) : 699-702. DOI: 10.1007/s13238-020-00769-9
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Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase

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Yechun Xu, Hualiang Jiang. Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase. Protein Cell, 2020, 11(10): 699‒702 https://doi.org/10.1007/s13238-020-00769-9

References

[1]
Boschi D, Pippione AC, Sainas S, Lolli ML (2019) Dihydroorotate dehydrogenase inhibitors in anti-infective drug research. Eur J Med Chem 183:111681
CrossRef Google scholar
[2]
Chi X, Yan R, Zhang J, Zhang G, Zhang Y, Hao M, Zhang Z, Fan P, Dong Y, Yang Y (2020) A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2. Science. https://doi.org/10.1126/science.abc6952
CrossRef Google scholar
[3]
Dai W, Zhang B, Jiang XM, Su H, Li J, Zhao Y, Xie X, Jin Z, Peng J, Liu F (2020) Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science 368:1331–1335
CrossRef Google scholar
[4]
Diao Y, Lu W, Jin H, Zhu J, Han L, Xu M, Gao R, Shen X, Zhao Z, Liu X (2012) Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening. J Med Chem 55:8341–8349
CrossRef Google scholar
[5]
Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, Wang T, Sun Q, Ming Z, Zhang L (2020) Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science 368:779–782
CrossRef Google scholar
[6]
Herrmann ML, Schleyerbach R, Kirschbaum BJ (2000) Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology 47:273–289
CrossRef Google scholar
[7]
Ji X, Li Z (2020) Medicinal chemistry strategies toward host targeting antiviral agents. Med Res Rev. https://doi.org/10.1002/med.21664
CrossRef Google scholar
[8]
Jin Z, Du X, Xu Y, Deng Y, Liu M, Zhao Y, Zhang B, Li X, Zhang L, Peng C (2020) Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature 582:289–293
CrossRef Google scholar
[9]
Li S, Luan G, Ren X, Song W, Xu L, Xu M, Zhu J, Dong D, Diao Y, Liu X (2015) Rational design of benzylidenehydrazinylsubstituted thiazole derivatives as potent inhibitors of human dihydroorotate dehydrogenase with in vivo anti-arthritic activity. Sci Rep 5:14836
CrossRef Google scholar
[10]
Loffler M, Fairbanks LD, Zameitat E, Marinaki AM, Simmonds HA (2005) Pyrimidine pathways in health and disease. Trends Mol Med 11:430–437
CrossRef Google scholar
[11]
Lolli ML, Sainas S, Pippione AC, Giorgis M, Boschi D, Dosio F (2018) Use of human dihydroorotate dehydrogenase (hDHODH) inhibitors in autoimmune diseases and new perspectives in cancer therapy. Recent Pat Anticancer Drug Discov 13:86–105
CrossRef Google scholar
[12]
Madak JT, Bankhead A 3rd, Cuthbertson CR, Showalter HD, Neamati N (2019) Revisiting the role of dihydroorotate dehydrogenase as a therapeutic target for cancer. Pharmacol Ther 195:111–131
CrossRef Google scholar
[13]
Reis RAG, Calil FA, Feliciano PR, Pinheiro MP, Nonato MC (2017) The dihydroorotate dehydrogenases: past and present. Arch Biochem Biophys 632:175–191
CrossRef Google scholar
[14]
Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, Shi Z, Hu Z, Zhong W, Xiao G (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res 30:269–271
CrossRef Google scholar
[15]
Xiong R, Zhang L, Li S, Sun Y, Ding M, Wang Y, Zhao Y, Wu Y, Shang W, Jiang X (2020) Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. Protein Cell. https://doi.org/10.1007/s13238-020-00768-w
CrossRef Google scholar
[16]
Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q (2020) Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science 367:1444–1448
CrossRef Google scholar
[17]
Yin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M (2020) Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science 368:1499–1504
CrossRef Google scholar
[18]
Zhang L, Lin D, Sun X, Curth U, Drosten C, Sauerhering L, Becker S, Rox K, Hilgenfeld R (2020) Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alphaketoamide inhibitors. Science 368:409–412
CrossRef Google scholar
[19]
Zhu J, Han L, Diao Y, Ren X, Xu M, Xu L, Li S, Li Q, Dong D, Huang J (2015) Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase. J Med Chem 58:1123–1139
CrossRef Google scholar

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