Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients

Jiangping He; Shuijiang Cai; Huijian Feng; Baomei Cai; Lihui Lin; Yuanbang Mai; Yinqiang Fan; Airu Zhu; Huang Huang; Junjie Shi; Dingxin Li; Yuanjie Wei; Yueping Li; Yingying Zhao; Yuejun Pan; He Liu; Xiaoneng Mo; Xi He; Shangtao Cao; FengYu Hu; Jincun Zhao; Jie Wang; Nanshan Zhong; Xinwen Chen; Xilong Deng; Jiekai Chen

doi:10.1007/s13238-020-00752-4

Protein Cell ›› 2020, Vol. 11 ›› Issue (9) : 680 -687. DOI: 10.1007/s13238-020-00752-4

LETTER

Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients

Jiangping He ¹^,³^,⁵
, Shuijiang Cai ²
, Huijian Feng ¹^,³^,⁵^,⁶
, Baomei Cai ¹^,³^,⁵
, Lihui Lin ¹^,³^,⁵^,⁶
, Yuanbang Mai ¹^,³^,⁵
, Yinqiang Fan ²
, Airu Zhu ⁴
, Huang Huang ²
, Junjie Shi ¹^,³^,⁵
, Dingxin Li ¹^,³^,⁵
, Yuanjie Wei ¹^,³^,⁵
, Yueping Li ²
, Yingying Zhao ¹^,³^,⁵
, Yuejun Pan ²
, He Liu ¹^,³^,⁵
, Xiaoneng Mo ²
, Xi He ²
, Shangtao Cao ¹^,³^,⁵
, FengYu Hu ²
, Jincun Zhao ⁴
, Jie Wang ¹^,³^,⁵
, Nanshan Zhong ⁴
, Xinwen Chen ¹^,⁵^,^†
, Xilong Deng ²^,^†
, Jiekai Chen ¹^,³^,⁵^,^†

Author information +

¹. Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

². Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou 510060, China

³. The Centre of Cell Lineage and Atlas (CCLA), Guangzhou Regenerative Medicine and Health-Guangdong Laboratory, Guangzhou 510530, China

⁴. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China

⁵. Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China

⁶. University of the Chinese Academy of Sciences, Beijing 100049, China

chen_xinwen@gibh.ac.cn (X. Chen)

gz8hdxl@126.com (X. Deng)

chen_jiekai@gibh.ac.cn (J. Chen)

Show less

History +

PDF (4072KB)

Cite this article

Download citation ▾

Jiangping He, Shuijiang Cai, Huijian Feng, Baomei Cai, Lihui Lin, Yuanbang Mai, Yinqiang Fan, Airu Zhu, Huang Huang, Junjie Shi, Dingxin Li, Yuanjie Wei, Yueping Li, Yingying Zhao, Yuejun Pan, He Liu, Xiaoneng Mo, Xi He, Shangtao Cao, FengYu Hu, Jincun Zhao, Jie Wang, Nanshan Zhong, Xinwen Chen, Xilong Deng, Jiekai Chen. Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients. Protein Cell, 2020, 11(9): 680-687 DOI:10.1007/s13238-020-00752-4

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Bian X-W, Team TC-P (2020) Autopsy of COVID-19 victims in China. National Science Review.

[2]	Bustamante-Marin XM, Ostrowski LE (2017) Cilia and mucociliary clearance. Cold Spring Harb Perspect Biol 9:28241

[3]

Cavalli G, De Luca G, Campochiaro C, Della-Torre E, Ripa M, Canetti D, Oltolini C, Castiglioni B, Tassan Din C, Boffini N (2020) Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study. Lancet Rheumatol 2:e325–e331

[4]	Chen AJ, Dong J, Yuan XH, Bo H, Li SZ, Wang C, Duan ZJ, Zheng LS (2019) Anti-H7N9 avian influenza A virus activity of interferon in pseudostratified human airway epithelium cell cultures. Virol J 16:44

[5]	Chivukula RR, Montoro DT, Leung HM, Yang J, Shamseldin HE, Taylor MS, Dougherty GW, Zariwala MA, Carson J, Daniels MLA (2020) A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nat Med 26:244–251

[6]	Demouveaux B, Gouyer V, Gottrand F, Narita T, Desseyn JL (2018) Gel-forming mucin interactome drives mucus viscoelasticity. Adv Colloid Interface Sci 252:69–82

[7]	Fahy JV, Dickey BF (2010) Airway mucus function and dysfunction. N Engl J Med 363:2233–2247

[8]	Fong IW (2017) Emerging animal coronaviruses: first SARS and now MERS. In: Emerging zoonoses, pp 63–80.

[9]	Krishn SR, Ganguly K, Kaur S, Batra SK (2018) Ramifications of secreted mucin MUC5AC in malignant journey: a holistic view. Carcinogenesis 39:633–651

[10]	Liao M, Liu Y, Yuan J, Wen Y, Xu G, Zhao J, Cheng L, Li J, Wang X, Wang F (2020) Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19. Nat Med

[11]	Lillehoj EP, Kato K, Lu W, Kim KC (2013) Cellular and molecular biology of airway mucins. Int Rev Cell Mol Biol 303:139–202

[12]	Liu Q, Wang RS, Qu GQ, Wang YY, Liu P, Zhu YZ, Fei G, Ren L, Zhou YW, Liu L (2020) Gross examination report of a COVID-19 death autopsy. Fa Yi Xue Za Zhi 36:21–23

[13]	Qian BZ, Li J, Zhang H, Kitamura T, Zhang J, Campion LR, Kaiser EA, Snyder LA, Pollard JW (2011) CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475:222–225

[14]	Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z (2019) Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis. Am J Respir Crit Care Med 199:1517–1536