Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

References

[1] Cho S, Lee YH, Park H, Ryoo K, Kang K, Park J, Eom SJ, Kim MJ, Chang TS, Choi SY (2001) Glutathione S-transferase Mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1. J Biol Chem 276:12749–12755

[2] Dorion S, Lambert H, Landry J (2002) Activation of the p38 signaling pathway by heat shock involves the dissociation of glutathione S-transferase Mu from Ask1. J Biol Chem 277:30792–30797

[3] Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X (2015) Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue. Diab. Metab Res Rev 31:433–452

[4] Kajimura S, Spiegelman Bruce M, Seale P (2015) Brown and beige fat: physiological roles beyond heat generation. Cell Metab 22:546–559

[5] Lu P, Zhang FC, Qian SW, Li X, Cui ZM, Dang YJ, Tang QQ (2016) Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function. Cell Res 26:1169–1172

[6] Ma XR, Xu LY, Alberobello AT, Gavrilova O, Bagattin A, Skarulis M, Liu J, Finkel T, Mueller E (2015) Celastrol protects against obesity and metabolic dysfunction through activation of a HSF1-PGC1α transcriptional axis. Cell Metab 22:695–708

[7] Mary Schultz SD, Tew Kenneth D (1997) Inhibitors of glutathione S-transferases as therapeutic agents. Adv Drug Deliv Rev 26:91–104

[8] Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450:712–716

[9] Nowack J, Arnold GS, Ruf T (2017) Muscle non-shivering thermogenesis and its role in the evolution of endothermy. Front Physiol 8:889

[10] Ohno H, Shinoda K, Spiegelman BM, Kajimura S (2012) PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab 15:395–404

[11] Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK (2018) Warming induces significant reprogramming of beige, but not brown, adipocyte cellular identity. Cell Metab 27:1121–1137

[12] Zhang Z, Zhang H, Li B, Meng X, Wang J, Zhang Y, Yao S, Ma Q, Jin L, Yang J (2014) Berberine activates thermogenesis in white and brown adipose tissue. Nat Commun 5:5493

[13] Zhou Y, Li W, Wang M, Zhang X, Zhang H, Tong X, Xiao Y (2016) Competitive profiling of celastrol targets in human cervical cancer HeLa cells via quantitative chemical proteomics. Mol BioSyst 13:83–91

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