Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

Zhaomeng Cui; Yang Liu; Wei Wan; Yuyan Xu; Yehui Hu; Meng Ding; Xin Dou; Ruina Wang; Hailing Li; Yongmei Meng; Wei Li; Wei Jiang; Zengxia Li; Yiming Li; Minjia Tan; Dengke K. Ma; Yu Ding; Jun O. Liu; Cheng Luo; Biao Yu; Qiqun Tang; Yongjun Dang

doi:10.1007/s13238-020-00717-7

Protein Cell ›› 2021, Vol. 12 ›› Issue (6) : 493 -501. DOI: 10.1007/s13238-020-00717-7

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Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes

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¹. Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200030, China

². Institute of Stem Cell Research and Regenerative Medicine, Institutes of Biomedical Sciences, Fudan University, Shanghai 200030, China

³. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

⁴. Department of Physiology and Biophysics, School of Life Sciences, Fudan University, Shanghai 200438, China

⁵. Henan Sesame Research Center, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China

⁶. College of Traditional Mongolian Medicine, Inner Mongolia Medical University, Mongolia 010110, China

⁷. State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

⁸. Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China

⁹. Department of Physiology, Cardiovascular Research Institute, University of California San Francisco, San Francisco, USA

¹⁰. Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

cluo@simm.ac.cn (C. Luo)

byu@sioc.ac.cn (B. Yu)

qqtang@shmu.edu.cn (Q. Tang)

yongjundang@fudan.edu.cn (Y. Dang)

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Zhaomeng Cui, Yang Liu, Wei Wan, Yuyan Xu, Yehui Hu, Meng Ding, Xin Dou, Ruina Wang, Hailing Li, Yongmei Meng, Wei Li, Wei Jiang, Zengxia Li, Yiming Li, Minjia Tan, Dengke K. Ma, Yu Ding, Jun O. Liu, Cheng Luo, Biao Yu, Qiqun Tang, Yongjun Dang. Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes. Protein Cell, 2021, 12(6): 493-501 DOI:10.1007/s13238-020-00717-7

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