Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver
Bingbing He, Wenbo Peng, Jia Huang, Hang Zhang, Yingsi Zhou, Xiali Yang, Jing Liu, Zhijie Li, Chunlong Xu, Mingxing Xue, Hui Yang, Pengyu Huang
Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver
[1] |
Chan JC, Piper DE, Cao Q, Liu D, King C, Wang W, Tang J, Liu Q, Higbee J, Xia Z
CrossRef
Google scholar
|
[2] |
Freije CA, Myhrvold C, Boehm CK, Lin AE, Welch NL, Carter A, Metsky HC, Luo CY, Abudayyeh OO, Gootenberg JS
CrossRef
Google scholar
|
[3] |
Haeusler RA, Hartil K, Vaitheesvaran B, Arrieta-Cruz I, Knight CM, Cook JR, Kammoun HL, Febbraio MA, Gutierrez-Juarez R, Kurland IJ
CrossRef
Google scholar
|
[4] |
Jackson AL, Bartz SR, Schelter J, Kobayashi SV, Burchard J, Mao M, Li B, Cavet G, Linsley PS (2003) Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 21:635–637
CrossRef
Google scholar
|
[5] |
Konermann S, Lotfy P, Brideau NJ, Oki J, Shokhirev MN, Hsu PD (2018) Transcriptome engineering with RNA-targeting type VI-D CRISPR effectors. Cell 173(665–676):e614
CrossRef
Google scholar
|
[6] |
Lambert G, Sjouke B, Choque B, Kastelein JJ, Hovingh GK (2012) The PCSK9 decade. J Lipid Res 53:2515–2524
CrossRef
Google scholar
|
[7] |
Li P, Ruan X, Yang L, Kiesewetter K, Zhao Y, Luo H, Chen Y, Gucek M, Zhu J, Cao H (2015) A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice. Cell Metab 21:455–467
CrossRef
Google scholar
|
[8] |
Moller DE (2012) Metabolic disease drug discovery- “hitting the target” is easier said than done. Cell Metab 15:19–24
CrossRef
Google scholar
|
[9] |
Pineda M, Lear A, Collins JP, Kiani S (2019) Safe CRISPR: challenges and possible solutions. Trends Biotechnol 37:389–401
CrossRef
Google scholar
|
[10] |
Price AA, Sampson TR, Ratner HK, Grakoui A, Weiss DS (2015) Cas9-mediated targeting of viral RNA in eukaryotic cells. Proc Natl Acad Sci USA 112:6164–6169
CrossRef
Google scholar
|
[11] |
Rossidis AC, Stratigis JD, Chadwick AC, Hartman HA, Ahn NJ, Li H, Singh K, Coons BE, Li L, Lv W
CrossRef
Google scholar
|
[12] |
Steinberg D, Witztum JL (2009) Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels. Proc Natl Acad Sci USA 106:9546–9547
CrossRef
Google scholar
|
[13] |
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA
CrossRef
Google scholar
|
[14] |
Yan WX, Chong S, Zhang H, Makarova KS, Koonin EV, Cheng DR, Scott DA (2018) Cas13d is a compact RNA-targeting type VI CRISPR effector positively modulated by a WYL-domain-containing accessory protein. Mol Cell 70(327–339):e325
CrossRef
Google scholar
|
[15] |
Zhou C, Hu X, Tang C, Liu W, Wang S, Zhou Y, Zhao Q, Bo Q, Shi L, Sun X
CrossRef
Google scholar
|
/
〈 | 〉 |